二甲双胍和冠脲在加拿大、美国和欧洲沿海水生环境中的发生、影响、分析和处理。

3区 生物学 Q1 Agricultural and Biological Sciences
Advances in Marine Biology Pub Date : 2018-01-01 Epub Date: 2018-11-07 DOI:10.1016/bs.amb.2018.09.005
Yunwen Tao, Bing Chen, Baiyu Helen Zhang, Zhiwen Joy Zhu, Qinhong Cai
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引用次数: 8

摘要

本文综述了二甲双胍和冠脲在加拿大、美国和欧洲沿海水生环境中的发生、影响、分析和处理。二甲双胍是化学分类上的双胍类药物,是治疗2型糖尿病最有效的一线口服药物之一。它很难被人体代谢,存在于这些地区的尿液和粪便样本中。冠脲是二甲双胍的生物转化产物。因此,二甲双胍和冠脲在污水处理厂和沿海水生环境中有显著浓度的报道。地表水样品中二甲双胍和冠脲的最高浓度分别高达59,000和4502ngL-1。二甲双胍可以被植物和大西洋鲑鱼(Salmo salar)的非目标生物吸收。冠脲在植物细胞中有丝分裂活性。目前二甲双胍的分析方法主要是高效液相色谱法(HPLC)和气相色谱-质谱法(GC-MS)。综述了二甲双胍在靶区水生环境中的去除情况。该综述有助于填补知识空白,并为监管考虑提供见解。还概述了管理这些新出现的污染物的潜在选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Occurrence, Impact, Analysis and Treatment of Metformin and Guanylurea in Coastal Aquatic Environments of Canada, USA and Europe.

This review discusses the occurrence, impact, analysis and treatment of metformin and guanylurea in coastal aquatic environments of Canada, USA and Europe. Metformin, a biguanide in chemical classification, is widely used as one of the most effective first-line oral drugs for type 2 diabetes. It is difficult to be metabolized by the human body and exists in both urine and faeces samples in these regions. Guanylurea is metformin's biotransformation product. Consequently, significant concentrations of metformin and guanylurea have been reported in wastewater treatment plants (WWTPs) and coastal aquatic environments. The maximum concentrations of metformin and guanylurea in surface water samples were as high as 59,000 and 4502ngL-1, respectively. Metformin can be absorbed in non-target organisms by plants and in Atlantic salmon (Salmo salar). Guanylurea has a confirmed mitotic activity in plant cells. Analysis methods of metformin are currently developed based on high-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS). The removal of metformin from aquatic environments in the target regions is summarized. The review helps to fill a knowledge gap and provides insights for regulatory considerations. The potential options for managing these emerging pollutants are outlined too.

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来源期刊
Advances in Marine Biology
Advances in Marine Biology MARINE & FRESHWATER BIOLOGY-
CiteScore
6.10
自引率
0.00%
发文量
6
审稿时长
12 months
期刊介绍: Advances in Marine Biology was first published in 1963 under the founding editorship of Sir Frederick S. Russell, FRS. Now edited by Charles Sheppard, the serial publishes in-depth and up-to-date reviews on a wide range of topics which will appeal to postgraduates and researchers in marine biology, fisheries science, ecology, zoology and biological oceanography. Eclectic volumes in the series are supplemented by thematic volumes on such topics as The Biology of Calanoid Copepods.
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