足月和早产儿缺氧缺血性脑病的磁共振成像表现:相关动物模型及其与人类影像学的相关性综述。

Q4 Medicine
Open Neuroimaging Journal Pub Date : 2018-10-17 eCollection Date: 2018-01-01 DOI:10.2174/1874440001812010055
Kyle A Jisa, Dillon D Clarey, Eric S Peeples
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引用次数: 11

摘要

背景:新生儿缺氧缺血性脑病是由灌注和氧输送减少引起的脑损伤,最常见于分娩并发症,如脐带压迫或胎盘早剥。成像是指导治疗和预测预后的关键组成部分,而对缺氧缺血性脑病的脑损伤模式最敏感的临床成像方式是磁共振成像。目的:本综述的目的是比较现有的缺氧缺血性脑病动物模型与早产儿(≤36周)和足月新生儿(>36周)缺氧缺血性脑病的磁共振成像结果,并特别注意每种模型的优缺点。方法:由两位作者独立进行结构化文献检索,并对检索结果进行汇总。记录动物模型、人脑年龄当量、损伤机制和脑损伤面积,与早产儿和足月人类缺氧缺血性脑病的影像学表现进行比较。结论:已经开发了许多动物模型,通过允许研究人员控制导致损伤的许多临床变量,从而更好地引出HIE后发生的预期结果。虽然模拟了相同的疾病过程,但在动物模型中的磁共振成像结果因动物种类和诱导缺氧和缺血的方法而异。HIE动物模型的进一步发展应包括将影像结果(而不仅仅是病理结果)与人类研究进行比较。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Magnetic Resonance Imaging Findings of Term and Preterm Hypoxic-Ischemic Encephalopathy: A Review of Relevant Animal Models and Correlation to Human Imaging.

Background: Neonatal hypoxic-ischemic encephalopathy is brain injury caused by decreased perfusion and oxygen delivery that most commonly occurs in the context of delivery complications such as umbilical cord compression or placental abruption. Imaging is a key component for guiding treatment and prediction of prognosis, and the most sensitive clinical imaging modality for the brain injury patterns seen in hypoxic-ischemic encephalopathy is magnetic resonance imaging.

Objective: The goal of this review is to compare magnetic resonance imaging findings demonstrated in the available animal models of hypoxic-ischemic encephalopathy to those found in preterm (≤ 36 weeks) and term (>36 weeks) human neonates with hypoxic-ischemic encephalopathy, with special attention to the strengths and weaknesses of each model.

Methods: A structured literature search was performed independently by two authors and the results of the searches were compiled. Animal model, human brain age equivalency, mechanism of injury, and area of brain injury were recorded for comparison to imaging findings in preterm and term human neonates with hypoxic-ischemic encephalopathy.

Conclusion: Numerous animal models have been developed to better elicit the expected findings that occur after HIE by allowing investigators to control many of the clinical variables that result in injury. Although modeling the same disease process, magnetic resonance imaging findings in the animal models vary with the species and methods used to induce hypoxia and ischemia. The further development of animal models of HIE should include a focus on comparing imaging findings, and not just pathologic findings, to human studies.

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来源期刊
Open Neuroimaging Journal
Open Neuroimaging Journal Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
0.70
自引率
0.00%
发文量
3
期刊介绍: The Open Neuroimaging Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, and letters in all important areas of brain function, structure and organization including neuroimaging, neuroradiology, analysis methods, functional MRI acquisition and physics, brain mapping, macroscopic level of brain organization, computational modeling and analysis, structure-function and brain-behavior relationships, anatomy and physiology, psychiatric diseases and disorders of the nervous system, use of imaging to the understanding of brain pathology and brain abnormalities, cognition and aging, social neuroscience, sensorimotor processing, communication and learning.
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