重组人生长激素(rhGH)时代的儿童生长激素缺乏症(GHD)。

4区医学 Q2 Medicine

Pediatric endocrinology reviews : PER Pub Date : 2018-09-01 DOI:10.17458/per.vol16.2018.r.ghdeficiencyrecombinant

Michael B Ranke

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引用次数: 5

摘要

在使用垂体提取hGH阶段(1958-1985)，积累了与诊断和治疗相关的基本经验。然而，随着重组生长激素(rhGH)的出现，GHD的诊断和治疗在世界范围内以一种更加标准化的方式进行。rhGH的治疗也伴随着大型国际药物流行病学调查的文件，这提供了新的见解。尽管有了这样的发展，儿童和青少年GHD的治疗仍然提出了与rhGH最有效和最安全的使用有关的问题。这篇简短的评论试图讨论与这些主题相关的几个方面，因为它们在rhGH时代发展起来。

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Pediatric Growth Hormone Deficiency (GHD) in the Recombinant Human GH (rhGH) Era.

During the phase of using hGH extracted from pituitaries (pit hGH) - 1958-1985 - fundamental experience related to the diagnosis and treatment was accumulated. However, since recombinant hGH (rhGH) had become available diagnosis and treatment of GHD were conducted world-wide in a more standardized way. Treatment with rhGH was also accompanied by documentations in large international pharmaco-epidemiological surveys, which provided new insight. Despite of this development the treatment of children and adolescents with GHD raises still issues related to the most effective and efficacious as well as safe use of rhGH. This brief review attempts to discuss a few aspects related to these topics as they have developed during the rhGH era.

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来源期刊

Pediatric endocrinology reviews : PER Medicine-Endocrinology, Diabetes and Metabolism

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期刊介绍： PEDIATRIC ENDOCRINOLOGY REVIEWS (PER) publishes scholarly review articles in all areas of clinical and experimental Endocrinology, Diabetes, Nutrition and Metabolism. PER is intended for practicing pediatricians, pediatric endocrinologists, pediatric diabetologists, pediatric gastroenterologists, neonatologists, pediatric gynecologists, nutritionists, sport physicians and pediatricians-in-training. PER will also publish topics on specific subjects or as proceedings of scientific meetings in the above fields of interest. All articles, whether invited or direct contributions, are peer-reviewed. PER publishes correspondence, book reviews, a meeting calendar and meeting reports.