红细胞分布宽度作为抗逆转录病毒治疗的hiv感染成人持续炎症和T细胞失调的易于测量的生物标志物。

Q2 Medicine
HIV Clinical Trials Pub Date : 2018-10-01 Epub Date: 2018-11-13 DOI:10.1080/15284336.2018.1514821
Zao Zhang, Glen M Chew, Cecilia M Shikuma, Louie Mar A Gangcuangco, Scott A Souza, Bruce Shiramizu, Beau K Nakamoto, Ting Gong, Santhosh R Mannem, Brooks I Mitchell, Kalpana J Kallianpur, Lishomwa C Ndhlovu, Dominic C Chow
{"title":"红细胞分布宽度作为抗逆转录病毒治疗的hiv感染成人持续炎症和T细胞失调的易于测量的生物标志物。","authors":"Zao Zhang,&nbsp;Glen M Chew,&nbsp;Cecilia M Shikuma,&nbsp;Louie Mar A Gangcuangco,&nbsp;Scott A Souza,&nbsp;Bruce Shiramizu,&nbsp;Beau K Nakamoto,&nbsp;Ting Gong,&nbsp;Santhosh R Mannem,&nbsp;Brooks I Mitchell,&nbsp;Kalpana J Kallianpur,&nbsp;Lishomwa C Ndhlovu,&nbsp;Dominic C Chow","doi":"10.1080/15284336.2018.1514821","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Chronic inflammation and immune dysfunction occur in human immunodeficiency virus (HIV)-infection despite stable antiretroviral therapy (ART). Red blood cell distribution width (RDW) has been shown to correlate with markers of inflammation in non-HIV conditions. The study objective was to determine associations between RDW with cellular markers of immune activation and immune dysfunction including soluble inflammatory mediators in ART treated HIV infection.</p><p><strong>Methods: </strong>We performed a cross-sectional analysis of the Hawaii Aging with HIV-Cardiovascular study. RDW was defined as one standard deviation of RBC size divided by mean corpuscular volume multiplied by 100%. Correlations were analyzed between RDW, soluble inflammatory biomarkers and T cell activation (CD38 + HLA-DR+), senescence (CD28-CD57+), and immune exhaustion (PD-1, TIGIT, TIM-3 expression).</p><p><strong>Results: </strong>Of 158 participants analyzed, median age was 50 years, duration of ART 12.6 years, virally suppressed 84.4%, and CD4 count 503 cells/mm3. Significant positive correlations were identified between RDW and soluble biomarkers including sICAM, IL-8, IL-6, SAA, TNF-α, sE-selection, fibrinogen, D-dimer, CRP, CD4/CD8 ratio, and frequency of multiple CD8 T-cell populations such as CD38 + HLA-DR + T-cells, single TIGIT+, and dual expressing of TIGIT + PD1+, TIGIT + TIM3+, and TIM3 + PD1+ CD8+ T-cell subsets (p < .05). Frequencies of CD38 + HLA-DR + CD8+ T-cells and TIGIT + CD8+ T-cells remained significant adjusting for baseline variables (p < .01).</p><p><strong>Conclusion: </strong>Our study revealed correlations between RDW with systemic inflammatory biomarkers and CD8+ T-cell populations related to immune activation and exhaustion in HIV-infected individuals on ART. Further studies are warranted to determine the utility of RDW as a marker of immune dysregulation in HIV.</p>","PeriodicalId":13216,"journal":{"name":"HIV Clinical Trials","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15284336.2018.1514821","citationCount":"10","resultStr":"{\"title\":\"Red blood cell distribution width as an easily measurable biomarker of persistent inflammation and T cell dysregulation in antiretrovirally treated HIV-infected adults.\",\"authors\":\"Zao Zhang,&nbsp;Glen M Chew,&nbsp;Cecilia M Shikuma,&nbsp;Louie Mar A Gangcuangco,&nbsp;Scott A Souza,&nbsp;Bruce Shiramizu,&nbsp;Beau K Nakamoto,&nbsp;Ting Gong,&nbsp;Santhosh R Mannem,&nbsp;Brooks I Mitchell,&nbsp;Kalpana J Kallianpur,&nbsp;Lishomwa C Ndhlovu,&nbsp;Dominic C Chow\",\"doi\":\"10.1080/15284336.2018.1514821\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Chronic inflammation and immune dysfunction occur in human immunodeficiency virus (HIV)-infection despite stable antiretroviral therapy (ART). Red blood cell distribution width (RDW) has been shown to correlate with markers of inflammation in non-HIV conditions. The study objective was to determine associations between RDW with cellular markers of immune activation and immune dysfunction including soluble inflammatory mediators in ART treated HIV infection.</p><p><strong>Methods: </strong>We performed a cross-sectional analysis of the Hawaii Aging with HIV-Cardiovascular study. RDW was defined as one standard deviation of RBC size divided by mean corpuscular volume multiplied by 100%. Correlations were analyzed between RDW, soluble inflammatory biomarkers and T cell activation (CD38 + HLA-DR+), senescence (CD28-CD57+), and immune exhaustion (PD-1, TIGIT, TIM-3 expression).</p><p><strong>Results: </strong>Of 158 participants analyzed, median age was 50 years, duration of ART 12.6 years, virally suppressed 84.4%, and CD4 count 503 cells/mm3. Significant positive correlations were identified between RDW and soluble biomarkers including sICAM, IL-8, IL-6, SAA, TNF-α, sE-selection, fibrinogen, D-dimer, CRP, CD4/CD8 ratio, and frequency of multiple CD8 T-cell populations such as CD38 + HLA-DR + T-cells, single TIGIT+, and dual expressing of TIGIT + PD1+, TIGIT + TIM3+, and TIM3 + PD1+ CD8+ T-cell subsets (p < .05). Frequencies of CD38 + HLA-DR + CD8+ T-cells and TIGIT + CD8+ T-cells remained significant adjusting for baseline variables (p < .01).</p><p><strong>Conclusion: </strong>Our study revealed correlations between RDW with systemic inflammatory biomarkers and CD8+ T-cell populations related to immune activation and exhaustion in HIV-infected individuals on ART. Further studies are warranted to determine the utility of RDW as a marker of immune dysregulation in HIV.</p>\",\"PeriodicalId\":13216,\"journal\":{\"name\":\"HIV Clinical Trials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/15284336.2018.1514821\",\"citationCount\":\"10\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"HIV Clinical Trials\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/15284336.2018.1514821\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2018/11/13 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"HIV Clinical Trials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/15284336.2018.1514821","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/11/13 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 10

摘要

背景:尽管抗逆转录病毒治疗(ART)稳定,但人类免疫缺陷病毒(HIV)感染仍会发生慢性炎症和免疫功能障碍。红细胞分布宽度(RDW)已被证明与非hiv条件下的炎症标志物相关。该研究的目的是确定RDW与抗逆转录病毒治疗HIV感染中免疫激活和免疫功能障碍的细胞标志物(包括可溶性炎症介质)之间的关系。方法:我们对夏威夷老化与hiv -心血管研究进行了横断面分析。RDW定义为RBC大小除以平均红细胞体积乘以100%的一个标准差。分析RDW、可溶性炎症生物标志物与T细胞活化(CD38 + HLA-DR+)、衰老(CD28-CD57+)和免疫衰竭(PD-1、TIGIT、TIM-3表达)之间的相关性。结果:在分析的158名参与者中,中位年龄为50岁,ART持续时间为12.6年,病毒抑制率为84.4%,CD4细胞计数为503个/mm3。RDW与可溶性生物标志物sICAM、IL-8、IL-6、SAA、TNF-α、sE-selection、纤维蛋白原、d -二聚体、CRP、CD4/CD8比值、CD8 t细胞群频率(CD38 + HLA-DR + t细胞、TIGIT+、TIGIT+ PD1+、TIGIT+ TIM3+、TIM3+ PD1+ CD8+ t细胞亚群)呈正相关(p)。我们的研究揭示了RDW与全身性炎症生物标志物和CD8+ t细胞群之间的相关性,这些细胞群与抗逆转录病毒治疗hiv感染者的免疫激活和衰竭有关。需要进一步的研究来确定RDW作为HIV免疫失调标志物的效用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Red blood cell distribution width as an easily measurable biomarker of persistent inflammation and T cell dysregulation in antiretrovirally treated HIV-infected adults.

Background: Chronic inflammation and immune dysfunction occur in human immunodeficiency virus (HIV)-infection despite stable antiretroviral therapy (ART). Red blood cell distribution width (RDW) has been shown to correlate with markers of inflammation in non-HIV conditions. The study objective was to determine associations between RDW with cellular markers of immune activation and immune dysfunction including soluble inflammatory mediators in ART treated HIV infection.

Methods: We performed a cross-sectional analysis of the Hawaii Aging with HIV-Cardiovascular study. RDW was defined as one standard deviation of RBC size divided by mean corpuscular volume multiplied by 100%. Correlations were analyzed between RDW, soluble inflammatory biomarkers and T cell activation (CD38 + HLA-DR+), senescence (CD28-CD57+), and immune exhaustion (PD-1, TIGIT, TIM-3 expression).

Results: Of 158 participants analyzed, median age was 50 years, duration of ART 12.6 years, virally suppressed 84.4%, and CD4 count 503 cells/mm3. Significant positive correlations were identified between RDW and soluble biomarkers including sICAM, IL-8, IL-6, SAA, TNF-α, sE-selection, fibrinogen, D-dimer, CRP, CD4/CD8 ratio, and frequency of multiple CD8 T-cell populations such as CD38 + HLA-DR + T-cells, single TIGIT+, and dual expressing of TIGIT + PD1+, TIGIT + TIM3+, and TIM3 + PD1+ CD8+ T-cell subsets (p < .05). Frequencies of CD38 + HLA-DR + CD8+ T-cells and TIGIT + CD8+ T-cells remained significant adjusting for baseline variables (p < .01).

Conclusion: Our study revealed correlations between RDW with systemic inflammatory biomarkers and CD8+ T-cell populations related to immune activation and exhaustion in HIV-infected individuals on ART. Further studies are warranted to determine the utility of RDW as a marker of immune dysregulation in HIV.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
HIV Clinical Trials
HIV Clinical Trials 医学-传染病学
CiteScore
1.76
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: HIV Clinical Trials is devoted exclusively to presenting information on the latest developments in HIV/AIDS clinical research. This journal enables readers to obtain the most up-to-date, innovative research from around the world.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信