在日本，人乳头瘤病毒的单一类型感染是导致高级别宫颈上皮内瘤变和浸润性癌的原因

IF 3.2

Papillomavirus Research Pub Date : 2018-12-01 DOI:10.1016/j.pvr.2018.10.001

Jinichi Sakamoto , Shoji Kamiura , Kaori Okayama , Mitsuaki Okodo , Takeo Shibata , Yasuhiro Osaka , Satoko Fujita , Emi Takata , Hiroaki Takagi , Masahiro Takakura , Toshiyuki Sasagawa

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引用次数: 28

摘要

为了阐明日本的致癌型人乳头瘤病毒(HPV)，采用新型的Genosearch-31+5 HPV检测对1526例宫颈上皮内瘤变(CIN)和371例浸润性宫颈癌(ICC)患者进行了HPV基因分型。CIN和ICC hpv阳性率分别为89.3%和90.8%。对于单一型感染，ICC中发现了13种国际公认的高危型(13HR)，不包括HPV 35，可能还有HR HPV 53、67、69和70，这表明所有这些类型都可能致癌。在SCC和腺癌(ADC)中均发现HPV16和18。HPV52、31和58 (α -9)在SCC中检出最多，而hpv18、45、39和59 (α -7)在ADC中检出最多。随着患者年龄的增加，SCC中HPV 18的患病率显著下降，而在其他HR类型中则相反。HPV18可能快速诱导SCC。所有年龄在20-29岁的ICC病例都对HPV 16或18呈阳性，这表明目前的HPV 16、18疫苗可能对预防年轻女性ICC非常有效。

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Single type infection of human papillomavirus as a cause for high-grade cervical intraepithelial neoplasia and invasive cancer in Japan

To elucidate oncogenic human papilloma virus (HPV) types in Japan, HPV genotyping was performed in 1526 cervical intraepithelial neoplasia (CIN) and 371 invasive cervical cancer (ICC) patients with the novel Genosearch-31+5 HPV test. The HPV-positive rates were 89.3% and 90.8% in CIN and ICC. Regarding single-type infections, 13 internationally recognized high-risk (13HR) types excluding HPV 35, and probably HR HPV 53, 67, 69, and 70 were identified in ICC, suggesting that all these types may be oncogenic. HPV16 and 18 were identified in both SCC and adenocarcinoma (ADC). HPV HPV52, 31 and 58 (alpha-9) were predominantly detected in SCC, whereas HPV 18, 45, 39 and 59 (alpha-7) were in ADC. The prevalence of HPV 18 in SCC significantly decreased with increasing age of patients, whereas the opposite trend was observed in the other HR types. HPV18 is likely to induce SCC rapidly. All ICC cases aged 20–29 were positive for HPV 16 or 18, suggesting that present HPV 16, 18 vaccines may be quite effective to prevent ICC in young women.

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来源期刊

Papillomavirus Research VIROLOGY-

自引率

0.00%

发文量

审稿时长

14 weeks

期刊介绍： The official Journal of the International Papillomavirus Society Papillomavirus Research (PVR), the Journal of HPV and other Small DNA Tumor Viruses publishes innovative papers related to all aspects of papillomaviruses and other small DNA tumor viruses. The official journal of the International Papillomavirus Society, PVR is an open access publication that aims to bring together virologists, immunologists, epidemiologists and clinicians working in the booming field of HPV and animal papillomaviruses, polyomaviruses and other small DNA tumor viruses and their associated diseases, in order to foster and facilitate interdisciplinary communication. The journal welcomes original research articles, reviews, short communications, opinion articles and regional update reports on papillomaviruses and other tumor viruses in the following sections: a. Biology of papillomaviruses and related viruses from life cycle to cancer b. Epidemiology etiology and natural history studies c. Natural and induced immunity including vaccine research d. Intervention studies and strategies including i. Clinical studies and trials ii. HPV treatments iii. HPV vaccination programs iv. Diagnostics and screening e. Infection and disease prevention, modeling studies f. Guidelines and public health recommendations g. HPV Studies in special populations Regional and local studies on these viruses.