E Danielle Sims, Sama Anvari, Yung Lee, Zainab Samaan, Laura Banfield, Lehana Thabane, M Constantine Samaan
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引用次数: 6
摘要
目的:一些国家正在使医用大麻的使用合法化，并放宽对其娱乐用途的限制。虽然成年人一直是这些举措的主要目标，但扩大获得大麻的机会可能会导致儿童使用大麻的增加。虽然对大麻对儿童神经心理和精神健康结果的影响进行了广泛的研究，但关于大麻对身体健康，包括内分泌健康的影响的数据有限。动物研究表明，长期使用大麻会导致性成熟延迟;然而，它对儿童青春期结局的影响还没有得到很好的研究。本系统综述旨在评估大麻使用对儿童青春期时间和节奏的影响。方法:我们对MEDLINE、Embase、Cochrane系统综述数据库、Central、PsycINFO、CINAHL、Web of Science和SPORTDiscus从成立到2018年2月的文献进行了系统综述。并在Clinicaltrials.gov和ProQuest dissertation and Theses A&I中完成灰色文献检索。主要指标为青春期发育时间，次要指标为青春期发育速度、最终身高和体重。我们对论文发表的日期和语言没有限制。两名审稿人独立评估记录的合格性，第三名审稿人解决分歧。结果:我们的数据库和灰色文献检索确定了759条记录。共有29篇全文论文被评估为合格。然而，所有的研究最终被排除，因为它们不符合资格标准。结论:我们的结果突出了现有文献中关于大麻使用对青春期影响的重大差距。迫切需要进行充分有力的纵向研究，以便向儿科医生和其他保健提供者提供关于大麻对儿童身体健康的潜在影响的高质量信息。系统评审注册的预期注册商:普洛斯彼罗号。: CRD42018089397。
The effect of cannabis exposure on pubertal outcomes: a systematic review.
Purpose: Several countries are legalizing the use of medicinal cannabis and easing restrictions on its recreational use. While adults have been the primary target of these initiatives, expanding access to cannabis will likely lead to increased use by children. While the effects of cannabis on pediatric neuropsychological and mental health outcomes have been broadly studied, there are limited data on the physical health effects of cannabis, including endocrine health. Animal studies have shown that chronic cannabis use leads to delayed sexual maturation; however, its effects on pubertal outcomes in children are not well studied. This systematic review aimed to assess the effect of cannabis use on pubertal timing and tempo in children.
Methods: We conducted a systematic review with literature searches in MEDLINE, Embase, Cochrane Database of Systematic Reviews, Central, PsycINFO, CINAHL, Web of Science, and SPORTDiscus from inception to February 2018. A gray literature search was also completed in Clinicaltrials.gov and ProQuest Dissertations and Theses A&I. The primary outcome was pubertal timing, while secondary outcomes included pubertal tempo and final height and weight. We had no restrictions on date or language of publication of papers. Two reviewers independently assessed records for eligibility, with a third reviewer resolving disagreements.
Results: Our database and gray literature searches identified 759 records. A total of 29 full-text papers were assessed for eligibility. However, all studies were ultimately excluded as they did not meet the eligibility criteria.
Conclusion: Our results highlight a significant gap in existing literature regarding the effects of cannabis use on puberty. Adequately powered longitudinal studies are urgently needed to provide pediatricians and other health care providers with high-quality information on the potential effects of cannabis on the physical health of children.
Prospective registrar of systematic reviews registration: PROSPERO no.: CRD42018089397.
期刊介绍：
Adolescent Health, Medicine and Therapeutics is an international, peer reviewed, open access journal focusing on health, pathology, and treatment issues specific to the adolescent age group, including health issues affecting young people with cancer. Original research, reports, editorials, reviews, commentaries and adolescent-focused clinical trial design are welcomed. All aspects of health maintenance, preventative measures, disease treatment interventions, studies investigating the poor outcomes for some treatments in this group of patients, and the challenges when transitioning from adolescent to adult care are addressed within the journal. Practitioners from all disciplines are invited to submit their work as well as health care researchers and patient support groups. Areas covered include: Physical and mental development in the adolescent period, Behavioral issues, Pathologies and treatment interventions specific to this age group, Prevalence and incidence studies, Diet and nutrition, Specific drug handling, efficacy, and safety issues, Drug development programs, Outcome studies, patient satisfaction, compliance, and adherence, Patient and health education programs and studies.
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