尸体垂体提取人类生长激素的时代(1958-1985):生物学和临床方面。

4区 医学 Q2 Medicine
Zvi Laron
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引用次数: 4

摘要

第一例用尸体垂体GH (hGH)治疗的患者于1958年报道。随后,许多国家开始收集尸体垂体,一些中心采用以下两种方法之一提取激素:a.丙酮保存和热冰醋酸提取(拉宾法)b.蒸馏水收集,冷冻,提取柱上有几种垂体激素,包括hGH (Wilhelmi法)。hGH的纯化提取物被发现具有代谢和生长刺激活性,但有限的量只允许治疗儿童GH缺乏症(GHD)。纯化后的激素还允许开发特异性放射免疫测定,从而研究生长激素的生理和药理作用。1985年,许多接受Wilhelmi hGH治疗多年的患者被诊断患有克雅氏病(CJD)。这导致抑制生长激素的生产和使用当时最近开发的生物合成重组生长激素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Era of Cadaveric Pituitary Extracted Human Growth Hormone (1958-1985):Biological and Clinical Aspects.

The first patient treated with cadaveric pituitary GH (hGH) was reported in 1958. Subsequently, collection of cadaveric pituitaries started in many countries and several centers extracted the hormone using one of two methods: a. Acetone preservation and extraction with hot glacial acetic acid (Rabin method) b. Collection in distilled water, freezing and extraction on columns yielding several pituitary hormones including hGH (Wilhelmi method). The purified extracts of hGH were found to have metabolic and growth stimulating activity but the limited amounts permitted the treatment only of children with GH deficiency (GHD). The purified hormone also permitted the development of specific radioimmunoassays enabling the study of the physiological and pharmacological actions of GH. In 1985 a number of patients treated years before with Wilhelmi hGH were diagnosed with Creutzfeld-Jacob-Disease (CJD). This led to the arrest of hGH production and the use of the then recently developed biosynthetic recombinant hGH.

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来源期刊
Pediatric endocrinology reviews : PER
Pediatric endocrinology reviews : PER Medicine-Endocrinology, Diabetes and Metabolism
自引率
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发文量
1
期刊介绍: PEDIATRIC ENDOCRINOLOGY REVIEWS (PER) publishes scholarly review articles in all areas of clinical and experimental Endocrinology, Diabetes, Nutrition and Metabolism. PER is intended for practicing pediatricians, pediatric endocrinologists, pediatric diabetologists, pediatric gastroenterologists, neonatologists, pediatric gynecologists, nutritionists, sport physicians and pediatricians-in-training. PER will also publish topics on specific subjects or as proceedings of scientific meetings in the above fields of interest. All articles, whether invited or direct contributions, are peer-reviewed. PER publishes correspondence, book reviews, a meeting calendar and meeting reports.
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