Mariana Diana Chaves de Almeida , Rodrigo Pires e Albuquerque , Guilherme Mathias Palhares , Juliana Patrícia Chaves de Almeida , João Mauricio Barretto , Naasson Cavanellas
{"title":"氨甲环酸在全膝关节置换术中的应用评价","authors":"Mariana Diana Chaves de Almeida , Rodrigo Pires e Albuquerque , Guilherme Mathias Palhares , Juliana Patrícia Chaves de Almeida , João Mauricio Barretto , Naasson Cavanellas","doi":"10.1016/j.rboe.2018.09.008","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>Evaluate the efficacy of tranexamic acid in reducing bleeding in patients undergoing total knee arthroplasty.</p></div><div><h3>Methods</h3><p>101 patients were randomized into two groups: the tranexamic acid group (<em>n</em> <!-->=<!--> <!-->51) and the placebo group (<em>n</em> <!-->=<!--> <!-->50). Patients were compared regarding the following parameters: reduction of hemoglobin, total estimated blood loss, drain output, and postoperative blood transfusion rate.</p></div><div><h3>Results</h3><p>Comparing the groups, there were statistically significant differences (<em>p</em> <!--><<!--> <!-->0.05) in the following parameters: reduction of hemoglobin, decreased hematocrit, estimated blood loss, and drain output. All values were lower in the tranexamic acid group. Only placebo group patients required blood transfusion.</p></div><div><h3>Conclusion</h3><p>The use of intravenous tranexamic acid is effective to reduce bleeding in patients undergoing total knee arthroplasty.</p></div>","PeriodicalId":101095,"journal":{"name":"Revista Brasileira de Ortopedia (English Edition)","volume":"53 6","pages":"Pages 761-767"},"PeriodicalIF":0.0000,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rboe.2018.09.008","citationCount":"3","resultStr":"{\"title\":\"Evaluation of the use of tranexamic acid in total knee arthroplasty\",\"authors\":\"Mariana Diana Chaves de Almeida , Rodrigo Pires e Albuquerque , Guilherme Mathias Palhares , Juliana Patrícia Chaves de Almeida , João Mauricio Barretto , Naasson Cavanellas\",\"doi\":\"10.1016/j.rboe.2018.09.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>Evaluate the efficacy of tranexamic acid in reducing bleeding in patients undergoing total knee arthroplasty.</p></div><div><h3>Methods</h3><p>101 patients were randomized into two groups: the tranexamic acid group (<em>n</em> <!-->=<!--> <!-->51) and the placebo group (<em>n</em> <!-->=<!--> <!-->50). Patients were compared regarding the following parameters: reduction of hemoglobin, total estimated blood loss, drain output, and postoperative blood transfusion rate.</p></div><div><h3>Results</h3><p>Comparing the groups, there were statistically significant differences (<em>p</em> <!--><<!--> <!-->0.05) in the following parameters: reduction of hemoglobin, decreased hematocrit, estimated blood loss, and drain output. All values were lower in the tranexamic acid group. Only placebo group patients required blood transfusion.</p></div><div><h3>Conclusion</h3><p>The use of intravenous tranexamic acid is effective to reduce bleeding in patients undergoing total knee arthroplasty.</p></div>\",\"PeriodicalId\":101095,\"journal\":{\"name\":\"Revista Brasileira de Ortopedia (English Edition)\",\"volume\":\"53 6\",\"pages\":\"Pages 761-767\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.rboe.2018.09.008\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Brasileira de Ortopedia (English Edition)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2255497118301228\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Brasileira de Ortopedia (English Edition)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2255497118301228","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Evaluation of the use of tranexamic acid in total knee arthroplasty
Objective
Evaluate the efficacy of tranexamic acid in reducing bleeding in patients undergoing total knee arthroplasty.
Methods
101 patients were randomized into two groups: the tranexamic acid group (n = 51) and the placebo group (n = 50). Patients were compared regarding the following parameters: reduction of hemoglobin, total estimated blood loss, drain output, and postoperative blood transfusion rate.
Results
Comparing the groups, there were statistically significant differences (p < 0.05) in the following parameters: reduction of hemoglobin, decreased hematocrit, estimated blood loss, and drain output. All values were lower in the tranexamic acid group. Only placebo group patients required blood transfusion.
Conclusion
The use of intravenous tranexamic acid is effective to reduce bleeding in patients undergoing total knee arthroplasty.
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