黑草鼻喷雾剂治疗无鼻息肉的慢性鼻窦炎疗效观察。

IF 2.3 Q1 OTORHINOLARYNGOLOGY
Allergy & Rhinology Pub Date : 2018-10-04 eCollection Date: 2018-01-01 DOI:10.1177/2152656718800059
Ahmad Rezaeian, Sanaz Amoushahi Khouzani
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引用次数: 12

摘要

背景:慢性鼻窦炎(CRS)是一种常见的鼻窦和副鼻窦炎症性疾病,有许多治疗方法可用于治疗此病。近年来,草药对CRS等炎症性疾病显示出显著的影响,其中一种草药是黑草。因此,本研究旨在评价芥蓝在CRS无鼻息肉(CRSsNP)患者中的疗效。方法:在这项随机临床试验中,根据纳入标准纳入65例轻至中度CRSsNP患者。患者随机分为干预组和安慰剂组。干预组患者接受2次/天的芥蓝鼻喷雾剂(1 g/天),安慰剂组患者接受2次/天0.65%的氯化钠喷雾剂。结果:干预组31例(男19例,女12例),安慰剂组34例(男18例,女16例)。治疗8周后对两组患者的隆德-麦凯、隆德-肯尼迪和鼻-鼻预后测试-22评分进行评估。两组的得分均显著下降。然而,干预组的这些评分明显低于安慰剂组(P)。结论:在crsssnp患者中,使用苜蓿鼻喷雾剂具有症状缓解作用,无不良反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effect of <i>Nigella sativa</i> Nasal Spray on the Treatment of Chronic Rhinosinusitis Without a Nasal Polyp.

Effect of <i>Nigella sativa</i> Nasal Spray on the Treatment of Chronic Rhinosinusitis Without a Nasal Polyp.

Effect of Nigella sativa Nasal Spray on the Treatment of Chronic Rhinosinusitis Without a Nasal Polyp.

Background: Chronic rhinosinusitis (CRS) is a common inflammatory disease of nasal and paranasal sinuses, with many treatment methods available for the management of this disease. Recently, herbal medicines have shown a significant impact on inflammatory diseases such as CRS, and one of these herbal medicines is Nigella sativa. Therefore, the current study aimed to evaluate the effectiveness of N. sativa in patients with CRS without nasal polyp (CRSsNP).

Methods: In this randomized clinical trial, 65 patients with mild to moderate CRSsNP were enrolled based on the inclusion criteria. Patients were divided randomly into 2 parallel groups: intervention and placebo groups. Patients in the intervention group received 2 puffs/day of N. sativa nasal spray (1 g/day of N. sativa) and in the placebo group received 2 puffs/day of sodium chloride spray 0.65%.

Results: Thirty-one patients (19 men and 12 women) in the intervention group and 34 in the placebo group (18 men and 16 women) were evaluated. Lund-McKay, Lund Kennedy, and Sino-Nasal Outcome Test-22 scores were assessed for both groups after 8 weeks of treatments. These scores decreased significantly in both groups. However, these scores were significantly lower in the intervention group compared with the placebo group (P < .0001, for all).

Conclusion: The use of N. sativa nasal spray has symptom reliever effect with no adverse effects in patients with CRSsNP.

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来源期刊
Allergy & Rhinology
Allergy & Rhinology OTORHINOLARYNGOLOGY-
CiteScore
3.30
自引率
4.50%
发文量
11
审稿时长
15 weeks
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