A comparison of blood pressure reductions following 12-weeks of isometric exercise training either in the laboratory or at home

Isometric exercise training (IET)–induced reductions in resting blood pressure (RBP) have been achieved in laboratory environments, but data in support of IET outside the laboratory are scarce. The aim of this study was to compare 12 weeks of home-based (HOM) IET with laboratory-based, face-to-face (LAB) IET in hypertensive adults. Twenty-two hypertensive participants (24–60 years) were randomized to three conditions: HOM, LAB, or control (CON). IET involved isometric handgrip training (4 × 2 minutes at 30% maximum voluntary contraction, 3 days per week). RBP was measured every 6 weeks (0, 6, and 12 weeks) during training and 6 weeks after training (18 weeks). Clinically meaningful, but not statistically significant reductions in RBP were observed after 12 weeks of LAB IET (resting systolic blood pressure [SBP] −9.1 ± 4.1; resting diastolic blood pressure [DBP] −2.8 ± 2.1; P > .05), which was sustained for 6 weeks of detraining (SBP −8.2 ± 2.9; DBP −4 ± 2.9, P > .05). RBP was reduced in the HOM group after 12 weeks of training (SBP −9.7 ± 3.4; DBP −2.2 ± 2.0; P > .05), which was sustained for an additional 6 weeks of detraining (SBP −5.5 ± 3.4; DBP −4.6 ± 1.8; P > .05). Unsupervised home-based IET programs present an exciting opportunity for community-based strategies to combat hypertension, but additional work is needed if IET is to be used routinely outside the laboratory.