S D Nabirochkin, S G Georgieva, T V Begetova, P G Georgiev, I V Makarova, T I Gerasimova, K G Gazaryan
{"title":"通过向胚胎的极性质中微量注射致癌病毒DNA诱导黑胃果蝇的不稳定突变:突变的插入性质。","authors":"S D Nabirochkin, S G Georgieva, T V Begetova, P G Georgiev, I V Makarova, T I Gerasimova, K G Gazaryan","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>MUTATIONS INDUCED BY THE MICROINJECTION OF ADENOVIRUS SA7 DNA INTO THE POLAR PLASM OF DROSOPHILA MELANOGASTER EMBRYOS WERE SHOWN TO BE OF THE INSERTIONAL TYPE. THE INSERTED ELEMENTS RESPONSIBLE FOR THESE MUTATIONS WERE ENDOGENOUS TRANSPOSONS RATHER THAN VIRAL SEQUENCES. THUS, GENETIC INSTABILITY ACTIVATED BY ONCOVIRAL DNA RESULTED FROM THE ABILITY OF THESE DNA SEQUENCES TO INDUCE TRANSPOSITION OF MOBILE ELEMENTS IN THE RECIPIENT GENOMES.</p>","PeriodicalId":78706,"journal":{"name":"Soviet genetics","volume":"27 4","pages":"421-7"},"PeriodicalIF":0.0000,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"INDUCTION OF UNSTABLE MUTATIONS IN DROSOPHILA MELANOGASTER BY THE MICROINJECTION OF ONCOGENIC VIRAL DNA INTO THE POLAR PLASM OF EMBRYOS: THE INSERTIONAL NATURE OF THE MUTATIONS.\",\"authors\":\"S D Nabirochkin, S G Georgieva, T V Begetova, P G Georgiev, I V Makarova, T I Gerasimova, K G Gazaryan\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>MUTATIONS INDUCED BY THE MICROINJECTION OF ADENOVIRUS SA7 DNA INTO THE POLAR PLASM OF DROSOPHILA MELANOGASTER EMBRYOS WERE SHOWN TO BE OF THE INSERTIONAL TYPE. THE INSERTED ELEMENTS RESPONSIBLE FOR THESE MUTATIONS WERE ENDOGENOUS TRANSPOSONS RATHER THAN VIRAL SEQUENCES. THUS, GENETIC INSTABILITY ACTIVATED BY ONCOVIRAL DNA RESULTED FROM THE ABILITY OF THESE DNA SEQUENCES TO INDUCE TRANSPOSITION OF MOBILE ELEMENTS IN THE RECIPIENT GENOMES.</p>\",\"PeriodicalId\":78706,\"journal\":{\"name\":\"Soviet genetics\",\"volume\":\"27 4\",\"pages\":\"421-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1991-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Soviet genetics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Soviet genetics","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
INDUCTION OF UNSTABLE MUTATIONS IN DROSOPHILA MELANOGASTER BY THE MICROINJECTION OF ONCOGENIC VIRAL DNA INTO THE POLAR PLASM OF EMBRYOS: THE INSERTIONAL NATURE OF THE MUTATIONS.
MUTATIONS INDUCED BY THE MICROINJECTION OF ADENOVIRUS SA7 DNA INTO THE POLAR PLASM OF DROSOPHILA MELANOGASTER EMBRYOS WERE SHOWN TO BE OF THE INSERTIONAL TYPE. THE INSERTED ELEMENTS RESPONSIBLE FOR THESE MUTATIONS WERE ENDOGENOUS TRANSPOSONS RATHER THAN VIRAL SEQUENCES. THUS, GENETIC INSTABILITY ACTIVATED BY ONCOVIRAL DNA RESULTED FROM THE ABILITY OF THESE DNA SEQUENCES TO INDUCE TRANSPOSITION OF MOBILE ELEMENTS IN THE RECIPIENT GENOMES.
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