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引用次数: 0
摘要
背景:帕金森病(PD)是第二常见的神经退行性疾病，与体重减轻和能量平衡有关。一些研究表明，瘦素可能在饱腹感、能量平衡和免疫反应中发挥重要作用。本研究的目的是评估PD患者的血清瘦素水平及其与临床严重程度的关系。方法:在这项横断面研究中，招募了年龄、性别和体重指数(BMI)相匹配的35例PD患者和51例健康对照(hc)。测定血清瘦素水平，记录患者临床特征及人口学资料。结果:PD和hc患者的平均年龄分别为59.80±11.40岁和62.18±11.60岁。PD与hc患者血清瘦素浓度差异无统计学意义(21.1±23.1 ng/ml vs 25.9±21.8 ng/ml, P = 0.280)。血浆瘦素水平与PD患者的临床严重程度无相关性。结论:我们的研究结果表明，血清瘦素水平与帕金森病的发病机制无关，也不会随着疾病的进展而下降。
Serum leptin levels in Iranian patients with Parkinson's disease.
Background: Parkinson's disease (PD), the second most prevalent neurodegenerative disorder, has been related with weight loss and energy balance. Some studies showed that leptin might be playing an important role in satiety, energy balance and immune response. The aim of this study was to evaluate serum leptin level in patients with PD and its association with clinical severity. Methods: In this cross-sectional study, 35 patients with PD and 51 healthy controls (HCs), matched for age, sex and body mass index (BMI), were recruited. Serum leptin level was measured and clinical characteristics and demographic data of patients were recorded. Results: The mean age of patients with PD and HCs were 59.80 ± 11.40 and 62.18 ± 11.60 years, respectively. Serum leptin concentration was not statistically different between patients with PD and HCs (21.1 ± 23.1 ng/ml vs 25.9 ± 21.8 ng/ml, P = 0.280). There was no relation between plasma level of leptin and clinical severity of patients with PD. Conclusion: Our findings suggest that serum level of leptin is neither implicated in the pathogenesis of PD, nor decreases as disease progresses.
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