E S Prokudina, L N Maslov, Yu V Bushov, M V Korobov, A A Podolskii, Sh Wang, Yu B Lishmanov
{"title":"[5-阿片受体参与心脏和线粒体适应慢性持续缺氧后对缺血再灌注影响的抵抗力增强]。","authors":"E S Prokudina, L N Maslov, Yu V Bushov, M V Korobov, A A Podolskii, Sh Wang, Yu B Lishmanov","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>It was investigated the involvement of cardiac Ϭ-opioid receptors (OR) in increasing the resistance of the heart and myocardial mitochondria to ischemia-reperfusion after adaptation rats to chronic continuous normobaric hypoxia (CCNH). Rats were subjected to CCNH for 21 days at 12 % O2. It was evoked global ischemia (45 minutes) and reperfusion (30 minutes) of the isolated perfused heart. Adaptation to CCNH promoted a reduction of creatine kinase release from necrotic cardiomyocytes during reperfusion and improved reperfusion recovery of heart contractility. Mitochondrial respiratory and state of MPT pore were more resistant to ischemia-reperfusion in adapting rats. Perfusion of isolated hearts with TIPP(0) (30 nM/l, a selective Ϭ-OR-antagonist) or naltriben (1 nM/l, a selective 52-OR-antagonist) completely eliminated the cardioprotective effect of CCNH. BNTX (1 nM/l, a selective Ϭ-OR-antagonist) had no effect on the cardioprotective effect of CCNH. This data suggest that cardiac 52-OR involved in the increased resistance of the heart and mitochondria to ischemia-reperfusion after adaptation rats to CCNH.</p>","PeriodicalId":21358,"journal":{"name":"Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova","volume":"102 10","pages":"1195-1205"},"PeriodicalIF":0.0000,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[INVOLVEMENT OF 5-OPIOID RECEPTORS IN THE INCREASED RESISTANCE OF HEART AND MITOCHONDRIA TO IMPACT OF ISCHEMIA-REPERFUSION AFTER ADAPTATION TO CHRONIC CONTINUOUS HYPOXIA].\",\"authors\":\"E S Prokudina, L N Maslov, Yu V Bushov, M V Korobov, A A Podolskii, Sh Wang, Yu B Lishmanov\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>It was investigated the involvement of cardiac Ϭ-opioid receptors (OR) in increasing the resistance of the heart and myocardial mitochondria to ischemia-reperfusion after adaptation rats to chronic continuous normobaric hypoxia (CCNH). Rats were subjected to CCNH for 21 days at 12 % O2. It was evoked global ischemia (45 minutes) and reperfusion (30 minutes) of the isolated perfused heart. Adaptation to CCNH promoted a reduction of creatine kinase release from necrotic cardiomyocytes during reperfusion and improved reperfusion recovery of heart contractility. Mitochondrial respiratory and state of MPT pore were more resistant to ischemia-reperfusion in adapting rats. Perfusion of isolated hearts with TIPP(0) (30 nM/l, a selective Ϭ-OR-antagonist) or naltriben (1 nM/l, a selective 52-OR-antagonist) completely eliminated the cardioprotective effect of CCNH. BNTX (1 nM/l, a selective Ϭ-OR-antagonist) had no effect on the cardioprotective effect of CCNH. This data suggest that cardiac 52-OR involved in the increased resistance of the heart and mitochondria to ischemia-reperfusion after adaptation rats to CCNH.</p>\",\"PeriodicalId\":21358,\"journal\":{\"name\":\"Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova\",\"volume\":\"102 10\",\"pages\":\"1195-1205\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[INVOLVEMENT OF 5-OPIOID RECEPTORS IN THE INCREASED RESISTANCE OF HEART AND MITOCHONDRIA TO IMPACT OF ISCHEMIA-REPERFUSION AFTER ADAPTATION TO CHRONIC CONTINUOUS HYPOXIA].
It was investigated the involvement of cardiac Ϭ-opioid receptors (OR) in increasing the resistance of the heart and myocardial mitochondria to ischemia-reperfusion after adaptation rats to chronic continuous normobaric hypoxia (CCNH). Rats were subjected to CCNH for 21 days at 12 % O2. It was evoked global ischemia (45 minutes) and reperfusion (30 minutes) of the isolated perfused heart. Adaptation to CCNH promoted a reduction of creatine kinase release from necrotic cardiomyocytes during reperfusion and improved reperfusion recovery of heart contractility. Mitochondrial respiratory and state of MPT pore were more resistant to ischemia-reperfusion in adapting rats. Perfusion of isolated hearts with TIPP(0) (30 nM/l, a selective Ϭ-OR-antagonist) or naltriben (1 nM/l, a selective 52-OR-antagonist) completely eliminated the cardioprotective effect of CCNH. BNTX (1 nM/l, a selective Ϭ-OR-antagonist) had no effect on the cardioprotective effect of CCNH. This data suggest that cardiac 52-OR involved in the increased resistance of the heart and mitochondria to ischemia-reperfusion after adaptation rats to CCNH.
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