羧酸辅助环烯基和烷基溴化物之间空间要求很高的还原性交叉偶联†

Organic chemistry frontiers : an international journal of organic chemistry Pub Date : 2023-01-01 DOI:10.1039/d3qo00155e

Jinglin An , Xue Zhou , Yifan Zhang , Zhenfei Ye , Qianyou Guo , Hao Song , Zhenlei Song , Xiao-Yu Liu , Yong Qin

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引用次数: 0

摘要

开发了2-溴环烯基羧酸和烷基溴化物之间的镍催化还原交叉偶联反应，以高达92%的中等至优异产率提供全碳四取代环烯烃。机理研究表明，羧酸基团在这种空间要求很高的偶联反应中起着重要的辅助作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Carboxylic acid-assisted sterically demanding reductive cross-coupling between cycloalkenyl and alkyl bromides†

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Carboxylic acid-assisted sterically demanding reductive cross-coupling between cycloalkenyl and alkyl bromides†

A nickel-catalysed reductive cross-coupling reaction between 2-bromo cycloalkenyl carboxylic acids and alkyl bromides has been developed, affording all-carbon tetrasubstituted cycloalkenes in moderate to excellent yields up to 92%. Mechanistic studies indicated that the carboxylic acid group plays an important assisting role in this sterically demanding coupling reaction.

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来源期刊

Organic chemistry frontiers : an international journal of organic chemistry

CiteScore

7.80

自引率

0.00%

发文量