渗透压对造影剂安全性的影响。

Q2 Medicine

Clinical and Molecular Allergy Pub Date : 2018-09-03 eCollection Date: 2018-01-01 DOI:10.1186/s12948-018-0097-4

Stefania Isola, Fabiana Furci, Sebastiano Gangemi

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引用次数: 2

摘要

背景:新型非离子造影剂分为低渗透压造影剂和等渗透压造影剂，它们具有不同的生化特性，可能影响其引起的过敏反应。我们研究的目的是评估渗透压如何影响造影剂使用的安全性。病例介绍:本研究包括6例有造影剂阳性反应史的患者。仅有1例患者穿刺皮内试验阳性。然而，有5例患者在使用造影剂后立即出现非IgE介导的反应。结论:在本研究中，我们重点研究了碘沙醇，一种异渗造影剂，发现该产品对既往造影剂过敏反应的患者具有良好的安全性。

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The involvement of osmolarity in the safety of contrast media.

Background: New non-ionic contrast agents, classified into low osmolar agents and iso-osmolar agents, present different biochemical characteristics that may influence the allergic reactions they cause. The aim of our study was to evaluate how osmolarity may affect safety in the use of contrast agents.

Case presentation: Six patients with a positive history for reaction to contrast agent were included in this study. Only one patient prick and intradermal skin test was positive. However, in 5 cases, patients presented an immediate reaction after administration of contrast agent that was not IgE mediated.

Conclusions: In this study, we focused on iodixanol, an iso-osmolar contrast agent, finding good safety of this product in patients with previous hypersensitivity reactions to contrast agent.

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来源期刊

Clinical and Molecular Allergy Medicine-Immunology and Allergy

CiteScore

8.20

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Clinical and Molecular Allergy is an open access, peer-reviewed, online journal that publishes research on human allergic and immunodeficient disease (immune deficiency not related to HIV infection/AIDS). The scope of the journal encompasses all aspects of the clinical, genetic, molecular and inflammatory aspects of allergic-respiratory (Type 1 hypersensitivity) and non-AIDS immunodeficiency disorders. However, studies of allergic/hypersensitive aspects of HIV infection/AIDS or drug desensitization protocols in AIDS are acceptable. At the basic science level, this includes original work and reviews on the genetic and molecular mechanisms underlying the inflammatory response.