慢性细菌性或炎症性前列腺炎患者长期使用舍拉酶、博斯韦利亚和松对精液细菌检测的差异增强作用,可能与不同程度的细菌粘附有关

IF 3.2 Q2 Pharmacology, Toxicology and Pharmaceutics
Enzo Vicari, Giulia Malaguarnera, Beatrice Ornella Vicari, Mario Salmeri, Michele Salemi, Roberto Castiglione
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引用次数: 1

摘要

背景:前列腺炎是一种男性复发性泌尿系统感染,通常难以治愈。该研究的目的是检查通过两个月的蛋白水解酶黏液活性(PEM)化合物(serrazzyme和其他成分)治疗,增强前列腺分泌物引流的抗炎作用是否影响精液培养物中细菌生长的定性或定量表达。方法:将450例前列腺炎综合征患者随机分为质子交换膜治疗组(干预组)和不治疗组。所有患者在2个月PEM连续治疗期(T2)结束时随访,停药后随访2个月(T4)。结果:107例慢性细菌性前列腺炎(CBP)患者中,15例(14.1%)经治疗后精液培养呈阴性,而cat - NIH-IIIA前列腺炎患者中,33.3%的低菌精患者精液培养呈阳性。停药两个月后,尽管与T2时观察到的匹配值相比,CBP患者的分离菌总数和菌落形成单位(CFU)计数没有明显变化,但炎症性前列腺炎患者的微生物参数变化明显。结论:本研究结果显示,PEM治疗2个月后,细菌粘附性和炎症性前列腺炎的减少,揭示了炎症性前列腺炎患者中微生物生物膜可能掩盖的与感染相关的明显炎症亚群。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Differentially Enhancing Effects of Long-term Treatment with Serrazyme, Boswellia and Pine on Seminal Bacterial Detection in Patients with Chronic Bacterial or Inflammatory Prostatitis, Probably Related to Several Degrees of Bacterial Adherence.

Background: Prostatitis is a recurrent urinary infection in males and is often difficult to cure. The aim of the study was to examine whether anti-inflammatory effects of enhanced drainage of prostatic secretions, obtained through two months treatment with a proteolytic enzyme mucoactive (PEM) compound (Serrazyme and other constituents), influenced qualitative or quantitative expressions of bacterial growth in seminal cultures.

Method: 450 patients with prostatitis syndromes were randomized either to PEM therapy (intervention group) or to no treatment group. All patients were followed at the end of a 2-month PEM continuous treatment period (T2) and further two months after withdrawal (T4).

Results: After treatment, 15 out of 107 (14.1%) patients with Chronic Bacterial Prostatitis (CBP) showed negative seminal cultures, while in patients with cat NIH-IIIA prostatitis seminal cultures became positive in 33.3% cases with low bacteriospermia. After two months from withdrawal, although among CBP patients the total number of isolates and colony forming units (CFU) counts showed not significant changes compared to matched-values observed at T2, microbial parameters varied significantly among inflammatory prostatitis patients.

Conclusion: The results of the present study showed that 2 months of treatment with PEM, decreasing bacterial adherence and inflammatory prostatitis, reveals a subgroup of apparent inflammation associated with infection that microbial biofilms likely mask in inflammatory prostatitis patients.

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来源期刊
Current clinical pharmacology
Current clinical pharmacology PHARMACOLOGY & PHARMACY-
CiteScore
3.60
自引率
0.00%
发文量
0
期刊介绍: Current Clinical Pharmacology publishes frontier reviews on all the latest advances in clinical pharmacology. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: pharmacokinetics; therapeutic trials; adverse drug reactions; drug interactions; drug metabolism; pharmacoepidemiology; and drug development. The journal is essential reading for all researchers in clinical pharmacology.
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