Joseph R. Blunck, Joseph W. Newman, Ronald K. Fields, John E. Croom
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Therapeutic augmentation of ketogenic diet with a sodium-glucose cotransporter 2 inhibitor in a super-refractory status epilepticus patient
Background
A ketogenic diet (KD) may have a role in treating patients in super-refractory status epilepticus (SRSE). Sodium-glucose cotransporter 2 (SGLT2) inhibitors have a risk of ketoacidosis that could facilitate induction of KD.
Case summary
A 42-year-old with a history of drug resistant epilepsy developed SRSE requiring several pharmacological interventions during her hospital course including the initiation of KD that failed. SGLT2 inhibitor therapy was initiated in a successful attempt to augment ketone production.
Conclusion
SGLT2 inhibitors may have a therapeutic value in SRSE patients who cannot achieve ketosis with KD alone.
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