{"title":"日本老年痴呆症患者使用第一代 H1 抗组胺药物的监测：回顾性队列研究","authors":"Toshiki Maeda, Akira Babazono, Takumi Nishi","doi":"10.1155/2018/3406210","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the rate of first-generation H1-antihistamines use for older adults with dementia in Japan.</p><p><strong>Methods: </strong>The study design was retrospective cohort using claims data between fiscal years 2010 and 2013. Subjects were 75 years or older, diagnosed with dementia, and given H1-antihistamines orally during the study period after being diagnosed with dementia. We investigated the cumulative number of oral H1-antihistamines administered and the relationship between first-generation H1-antihistamine use and each explanatory variable using crude and adjusted odds ratio.</p><p><strong>Results: </strong>The cumulative total for use of first-generation H1-antihistamine for older adults with dementia accounted for 32.1% of all antihistamine medication. The majority of first-generation H1-antihistamine prescriptions were indicated for cold treatment. Those with upper respiratory infection or asthma had a significantly positive relationship with first-generation H1-antihistamine use.</p><p><strong>Conclusion: </strong>The study showed that first-generation H1-antihistamine drugs were highly prescribed in older adults with dementia in Japan.</p>","PeriodicalId":39066,"journal":{"name":"Current Gerontology and Geriatrics Research","volume":"2018 ","pages":"3406210"},"PeriodicalIF":0.0000,"publicationDate":"2018-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051324/pdf/","citationCount":"0","resultStr":"{\"title\":\"Surveillance of First-Generation H1-Antihistamine Use for Older Patients with Dementia in Japan: A Retrospective Cohort Study.\",\"authors\":\"Toshiki Maeda, Akira Babazono, Takumi Nishi\",\"doi\":\"10.1155/2018/3406210\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>This study aimed to investigate the rate of first-generation H1-antihistamines use for older adults with dementia in Japan.</p><p><strong>Methods: </strong>The study design was retrospective cohort using claims data between fiscal years 2010 and 2013. Subjects were 75 years or older, diagnosed with dementia, and given H1-antihistamines orally during the study period after being diagnosed with dementia. We investigated the cumulative number of oral H1-antihistamines administered and the relationship between first-generation H1-antihistamine use and each explanatory variable using crude and adjusted odds ratio.</p><p><strong>Results: </strong>The cumulative total for use of first-generation H1-antihistamine for older adults with dementia accounted for 32.1% of all antihistamine medication. The majority of first-generation H1-antihistamine prescriptions were indicated for cold treatment. Those with upper respiratory infection or asthma had a significantly positive relationship with first-generation H1-antihistamine use.</p><p><strong>Conclusion: </strong>The study showed that first-generation H1-antihistamine drugs were highly prescribed in older adults with dementia in Japan.</p>\",\"PeriodicalId\":39066,\"journal\":{\"name\":\"Current Gerontology and Geriatrics Research\",\"volume\":\"2018 \",\"pages\":\"3406210\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-07-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051324/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Gerontology and Geriatrics Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2018/3406210\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2018/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Gerontology and Geriatrics Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2018/3406210","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Surveillance of First-Generation H1-Antihistamine Use for Older Patients with Dementia in Japan: A Retrospective Cohort Study.
Background: This study aimed to investigate the rate of first-generation H1-antihistamines use for older adults with dementia in Japan.
Methods: The study design was retrospective cohort using claims data between fiscal years 2010 and 2013. Subjects were 75 years or older, diagnosed with dementia, and given H1-antihistamines orally during the study period after being diagnosed with dementia. We investigated the cumulative number of oral H1-antihistamines administered and the relationship between first-generation H1-antihistamine use and each explanatory variable using crude and adjusted odds ratio.
Results: The cumulative total for use of first-generation H1-antihistamine for older adults with dementia accounted for 32.1% of all antihistamine medication. The majority of first-generation H1-antihistamine prescriptions were indicated for cold treatment. Those with upper respiratory infection or asthma had a significantly positive relationship with first-generation H1-antihistamine use.
Conclusion: The study showed that first-generation H1-antihistamine drugs were highly prescribed in older adults with dementia in Japan.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
