[跨代表观遗传效应:高温对果蝇寿命的影响]。

Pub Date : 2016-11-01
N Ya Weisman, M D Golubovsky
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引用次数: 0

摘要

表观遗传现象被定义为与DNA序列损伤无关的形态生理变化。我们的研究结果表明,对发育中的卵子(前胚胎)施加脉冲非诱变热应激会导致后代寿命的积极跨代表观遗传变化。在这种情况下,这种效应取决于从母亲那里遗传的lgl突变的杂合性。在第Fl代,甚至在卵发生的早期阶段就决定了更高的生存性状。在前胚胎发育的最初阶段对细胞进行加热时,观察到的效果最为明显。本研究是首次模拟肿瘤抑制因子lgl作用下,合子前(胚胎前)应激对后代生存能力和寿命的跨代影响的实验研究。讨论了这些结果在人类表观遗传学方面的意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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[Transgenerational epigenetic effects: The influence of heightened temperature on Drosophila melanogaster life span].

Epigenetic phenomena are defined as morpho-physiological changes not related to impairments of DNA sequence. The results of our study indicate that a pulsed non-mutagenic thermal stress inflicted on developing ova (pro-embryos) gives rise to positive transgenerational epigenetic changes in the life span of offspring. At that, this effect depends on heterozygosity by lgl-mutation inherited from mothers. In generation Fl, determination of higher survival trait occurs even at early stages of oogenesis. The most pronounced effect is observed when heating is applied to the cells at the earliest stages of pro-embryo development. This study is the first experimental work on modeling the transgenerational aftereffects of pre-zygotic (pro-embryo) stress on offspring survivability and longevity when tumor suppressor lgl is operating. The significance of the results with regard to human epigenetics is discussed.

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