[肾阳虚抑郁模型大鼠肝脏药物代谢酶的变化]。

药学学报 Pub Date : 2017-02-01

Shu-fen He, Wen-zheng Ju, Hao-bin Hu, Li-jing Zhu, Qian Zhang, Guo-liang Dai

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引用次数: 0

摘要

本研究旨在探讨抑郁症对肾阳虚大鼠的影响。大鼠反复注射氢化可的松21 d，建立肾阳虚抑郁模型。以甲苯丁胺、氯唑酮、茶碱、咪达唑仑、奥美拉唑和右美沙芬作为CYP2C6、CYP2E1、CYP1A2、CYP3A2、CYP2D1和CYP2D2的底物，检测其对药物代谢的抑制作用。采用LC-MS/MS法测定6种CYP450的血药浓度，并将其作为药动学参数。因此，与对照组相比，茶碱、氯唑唑酮和甲苯丁胺的代谢显著加快(P < 0.01)，而右美沙芬、奥美拉唑和咪达唑仑的代谢无显著差异。本研究提示，在大鼠模型中，抑郁伴肾阳虚对CYP2E1的诱导作用较强，对CYP1A2、CYP2C6的诱导作用中等。

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本刊更多论文

[Change of hepatic drug metabolism enzymes in rat depression model with kidney-yang deficiency].

This study was designed to explore the impact of depression on kidney-yang deficiency in rats. Rats were repeatedly injected with hydrocortisone for 21 days to establish the depression model with kidneyyang deficiency. Tolbutamide, chlorzoxazone, theophylline, midazolam, omeprazole and dextromethorphan were used as substrates of CYP2C6, CYP2E1, CYP1A2, CYP3A2, CYP2D1, and CYP2D2 to test the depression impact on drug metabolism. Plasma concentrations of six CYP450 were determined by LC-MS/MS and used as pharmacokinetic parameters. Consequently, metabolism of theophylline, chlorzoxazone and tolbutamide were accelerated significantly in the model relative to the control (P < 0.01), but dextromethorphan, omeprazole and midazolam did not exhibit a significant difference. The present study suggests that depression with kidneyyang deficiency had a strong induction of CYP2E1 and moderate induction of CYP1A2, CYP2C6 in the rat model.

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来源期刊

药学学报 Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Acta Pharmaceutica Sinica B (APSB) is a bimonthly English peer-reviewed online journal in ScienceDirect, which publishes significant original research articles, communications and high quality reviews of recent advances. APSB encourages submissions from all areas of pharmaceutical sciences, including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics. APSB is a part of the series Acta Pharmaceutica Sinica, which was founded in 1953. The journal is co-published by Elsevier B.V., in association with the Institute of MateriaMedica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association.