Kelsey Gabel, Kristin K Hoddy, Nicole Haggerty, Jeehee Song, Cynthia M Kroeger, John F Trepanowski, Satchidananda Panda, Krista A Varady
{"title":"8小时限食对肥胖成人体重和代谢性疾病危险因素的影响:一项初步研究","authors":"Kelsey Gabel, Kristin K Hoddy, Nicole Haggerty, Jeehee Song, Cynthia M Kroeger, John F Trepanowski, Satchidananda Panda, Krista A Varady","doi":"10.3233/NHA-170036","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Time restricted feeding decreases energy intake without calorie counting and may be a viable option for weight loss. However, the effect of this diet on body weight in obese subjects has never been examined.</p><p><strong>Objective: </strong>This study investigated the effects of 8-h time restricted feeding on body weight and metabolic disease risk factors in obese adults.</p><p><strong>Design: </strong>Obese subjects (<i>n</i> = 23) participated in an 8-h time restricted feeding intervention (ad libitum feeding between 10:00 to 18:00 h, water fasting between 18:00 to 10:00 h) for 12 weeks. Weight loss and other outcomes were compared to a matched historical control group (<i>n</i> = 23).</p><p><strong>Results: </strong>Body weight and energy intake decreased in the time restricted group (-2.6% ± 0.5; -341 ± 53 kcal/d) relative to controls over 12 weeks (<i>P</i> < 0.05). Systolic blood pressure decreased in the time restricted feeding group (-7 ± 2 mm Hg) versus controls (<i>P</i> < 0.05). Fat mass, lean mass, visceral fat mass, diastolic blood pressure, LDL cholesterol, HDL cholesterol, triglycerides, fasting glucose, fasting insulin, HOMA-IR, and homocysteine were not significantly different from controls after 12 weeks (no group×time interaction).</p><p><strong>Conclusion: </strong>These findings suggest that 8-h time restricted feeding produces mild caloric restriction and weight loss, without calorie counting. It may also offer clinical benefits by reducing blood pressure.</p>","PeriodicalId":37419,"journal":{"name":"Nutrition and Healthy Aging","volume":"4 4","pages":"345-353"},"PeriodicalIF":0.0000,"publicationDate":"2018-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NHA-170036","citationCount":"340","resultStr":"{\"title\":\"Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: A pilot study.\",\"authors\":\"Kelsey Gabel, Kristin K Hoddy, Nicole Haggerty, Jeehee Song, Cynthia M Kroeger, John F Trepanowski, Satchidananda Panda, Krista A Varady\",\"doi\":\"10.3233/NHA-170036\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Time restricted feeding decreases energy intake without calorie counting and may be a viable option for weight loss. However, the effect of this diet on body weight in obese subjects has never been examined.</p><p><strong>Objective: </strong>This study investigated the effects of 8-h time restricted feeding on body weight and metabolic disease risk factors in obese adults.</p><p><strong>Design: </strong>Obese subjects (<i>n</i> = 23) participated in an 8-h time restricted feeding intervention (ad libitum feeding between 10:00 to 18:00 h, water fasting between 18:00 to 10:00 h) for 12 weeks. Weight loss and other outcomes were compared to a matched historical control group (<i>n</i> = 23).</p><p><strong>Results: </strong>Body weight and energy intake decreased in the time restricted group (-2.6% ± 0.5; -341 ± 53 kcal/d) relative to controls over 12 weeks (<i>P</i> < 0.05). Systolic blood pressure decreased in the time restricted feeding group (-7 ± 2 mm Hg) versus controls (<i>P</i> < 0.05). Fat mass, lean mass, visceral fat mass, diastolic blood pressure, LDL cholesterol, HDL cholesterol, triglycerides, fasting glucose, fasting insulin, HOMA-IR, and homocysteine were not significantly different from controls after 12 weeks (no group×time interaction).</p><p><strong>Conclusion: </strong>These findings suggest that 8-h time restricted feeding produces mild caloric restriction and weight loss, without calorie counting. It may also offer clinical benefits by reducing blood pressure.</p>\",\"PeriodicalId\":37419,\"journal\":{\"name\":\"Nutrition and Healthy Aging\",\"volume\":\"4 4\",\"pages\":\"345-353\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-06-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3233/NHA-170036\",\"citationCount\":\"340\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutrition and Healthy Aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3233/NHA-170036\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition and Healthy Aging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3233/NHA-170036","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: A pilot study.
Background: Time restricted feeding decreases energy intake without calorie counting and may be a viable option for weight loss. However, the effect of this diet on body weight in obese subjects has never been examined.
Objective: This study investigated the effects of 8-h time restricted feeding on body weight and metabolic disease risk factors in obese adults.
Design: Obese subjects (n = 23) participated in an 8-h time restricted feeding intervention (ad libitum feeding between 10:00 to 18:00 h, water fasting between 18:00 to 10:00 h) for 12 weeks. Weight loss and other outcomes were compared to a matched historical control group (n = 23).
Results: Body weight and energy intake decreased in the time restricted group (-2.6% ± 0.5; -341 ± 53 kcal/d) relative to controls over 12 weeks (P < 0.05). Systolic blood pressure decreased in the time restricted feeding group (-7 ± 2 mm Hg) versus controls (P < 0.05). Fat mass, lean mass, visceral fat mass, diastolic blood pressure, LDL cholesterol, HDL cholesterol, triglycerides, fasting glucose, fasting insulin, HOMA-IR, and homocysteine were not significantly different from controls after 12 weeks (no group×time interaction).
Conclusion: These findings suggest that 8-h time restricted feeding produces mild caloric restriction and weight loss, without calorie counting. It may also offer clinical benefits by reducing blood pressure.
期刊介绍：
Nutrition and Healthy Aging is an international forum for research on nutrition as a means of promoting healthy aging. It is particularly concerned with the impact of nutritional interventions on the metabolic and molecular mechanisms which modulate aging and age-associated diseases, including both biological responses on the part of the organism itself and its micro biome. Results emanating from both model organisms and clinical trials will be considered. With regards to the latter, the journal will be rigorous in only accepting for publication well controlled, randomized human intervention trials that conform broadly with the current EFSA and US FDA guidelines for nutritional clinical studies. The journal will publish research articles, short communications, critical reviews and conference summaries, whilst open peer commentaries will be welcomed.
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