原肠爪蟾的细胞迁移。

Q1 Biochemistry, Genetics and Molecular Biology
Yunyun Huang, Rudolf Winklbauer
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引用次数: 19

摘要

非洲爪蟾原肠胚形成运动在很大程度上是基于细胞在多层组织内的细胞间迁移的重排。基于迁移的不同细胞嵌入模式驱动内胚层和中胚层的内化及其沿其未来体轴的定位。c -钙粘蛋白、纤维连接蛋白、整合素和局灶接触成分在所有原肠原细胞中表达,并在细胞间迁移中发挥假定的作用,但它们在这方面的实际功能尚不清楚。原肠原管可细分为两个运动域,在植物迁移域,细胞迁移可分为两种模式。植物内胚层细胞表现为侵袭型迁移,这是变形虫迁移的一种变体,其特征是缺乏运动性突起,并通过巨噬细胞作用作为后缘吸收的机制。中胚层细胞和脊索前中胚层细胞以间充质迁移方式利用板足。原肠细胞的运动可以分解为一些特征,如细胞极性、粘附性、移动性或突出性,这些特征是单独控制的,但又以复杂的组合方式控制。细胞可以在不同的特征组合之间瞬间切换,在对基质属性做出反应时显示出可塑性。本文分类为:早期胚胎发育>原肠胚形成和神经发育。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cell migration in the Xenopus gastrula.

Xenopus gastrulation movements are in large part based on the rearrangement of cells by differential cell-on-cell migration within multilayered tissues. Different patterns of migration-based cell intercalation drive endoderm and mesoderm internalization and their positioning along their prospective body axes. C-cadherin, fibronectin, integrins, and focal contact components are expressed in all gastrula cells and play putative roles in cell-on-cell migration, but their actual functions in this respect are not yet understood. The gastrula can be subdivided into two motility domains, and in the vegetal, migratory domain, two modes of cell migration are discerned. Vegetal endoderm cells show ingression-type migration, a variant of amoeboid migration characterized by the lack of locomotory protrusions and by macropinocytosis as a mechanism of trailing edge resorption. Mesendoderm and prechordal mesoderm cells use lamellipodia in a mesenchymal mode of migration. Gastrula cell motility can be dissected into traits, such as cell polarity, adhesion, mobility, or protrusive activity, which are controlled separately yet in complex, combinatorial ways. Cells can instantaneously switch between different combinations of traits, showing plasticity as they respond to substratum properties. This article is categorized under: Early Embryonic Development > Gastrulation and Neurulation.

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来源期刊
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期刊介绍: Developmental biology is concerned with the fundamental question of how a single cell, the fertilized egg, ultimately produces a complex, fully patterned adult organism. This problem is studied on many different biological levels, from the molecular to the organismal. Developed in association with the Society for Developmental Biology, WIREs Developmental Biology will provide a unique interdisciplinary forum dedicated to fostering excellence in research and education and communicating key advances in this important field. The collaborative and integrative ethos of the WIREs model will facilitate connections to related disciplines such as genetics, systems biology, bioengineering, and psychology. The topical coverage of WIREs Developmental Biology includes: Establishment of Spatial and Temporal Patterns; Gene Expression and Transcriptional Hierarchies; Signaling Pathways; Early Embryonic Development; Invertebrate Organogenesis; Vertebrate Organogenesis; Nervous System Development; Birth Defects; Adult Stem Cells, Tissue Renewal and Regeneration; Cell Types and Issues Specific to Plants; Comparative Development and Evolution; and Technologies.
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