弱视的动物模型。

IF 1.1 4区 医学 Q4 NEUROSCIENCES
Donald Mitchell, Frank Sengpiel
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引用次数: 10

摘要

毫无疑问,过去60年对各种动物模型的研究提高了我们对弱视许多复杂特征背后机制的理解,并为治疗提供了有希望的新途径。虽然动物模型总体上起到了重要的作用,但考虑到动物物种之间的差异,特别是当目标是为人类干预提供基础时,关于特定模型的有效性仍然存在问题。我们对这些问题的讨论最终形成了对未来研究的三项建议,以提供跨动物模型的凝聚力,以及第四项建议,即接受将特定动物模型上获得的结果转化为人类临床试验所需的最少步骤的协议。对未来研究的三个建议来自于对各种问题的讨论,包括使用不同动物模型获得的具体结果,与人类视觉系统的相似程度,生成不同类型人类弱视动物模型的能力以及确定不同物种之间发育时间表的难度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Animal models of amblyopia.

Unquestionably, the last six decades of research on various animal models have advanced our understanding of the mechanisms that underlie the many complex characteristics of amblyopia as well as provided promising new avenues for treatment. While animal models in general have served an important purpose, there nonetheless remain questions regarding the efficacy of particular models considering the differences across animal species, especially when the goal is to provide the foundations for human interventions. Our discussion of these issues culminated in three recommendations for future research to provide cohesion across animals models as well as a fourth recommendation for acceptance of a protocol for the minimum number of steps necessary for the translation of results obtained on particular animal models to human clinical trials. The three recommendations for future research arose from discussions of various issues including the specific results obtained from the use of different animal models, the degree of similarity to the human visual system, the ability to generate animal models of the different types of human amblyopia as well as the difficulty of scaling developmental timelines between different species.

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来源期刊
Visual Neuroscience
Visual Neuroscience 医学-神经科学
CiteScore
2.20
自引率
5.30%
发文量
8
审稿时长
>12 weeks
期刊介绍: Visual Neuroscience is an international journal devoted to the publication of experimental and theoretical research on biological mechanisms of vision. A major goal of publication is to bring together in one journal a broad range of studies that reflect the diversity and originality of all aspects of neuroscience research relating to the visual system. Contributions may address molecular, cellular or systems-level processes in either vertebrate or invertebrate species. The journal publishes work based on a wide range of technical approaches, including molecular genetics, anatomy, physiology, psychophysics and imaging, and utilizing comparative, developmental, theoretical or computational approaches to understand the biology of vision and visuo-motor control. The journal also publishes research seeking to understand disorders of the visual system and strategies for restoring vision. Studies based exclusively on clinical, psychophysiological or behavioral data are welcomed, provided that they address questions concerning neural mechanisms of vision or provide insight into visual dysfunction.
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