韩国成人类风湿关节炎和呼吸道变应性疾病的相关性:倾向评分匹配病例对照研究

IF 2.3 Q2 RHEUMATOLOGY
International Journal of Rheumatology Pub Date : 2018-04-23 eCollection Date: 2018-01-01 DOI:10.1155/2018/3798124
Han Eol Jeong, Sung-Mok Jung, Sung-Il Cho
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引用次数: 15

摘要

类风湿关节炎(RA)和过敏性疾病是免疫系统功能低下的结果,分别由t -辅助性1 (Th1)或t -辅助性2 (Th2)疾病主导。研究表明,免疫反应亚群之间似乎存在某种关系。本研究旨在探讨韩国成人风湿性关节炎与呼吸道变态反应性疾病之间的关系。该研究使用了KNHANES 2013-2015数据,并排除了在诊断为过敏性疾病之前诊断为RA的个体,使用临床诊断时的年龄。共有253例RA患者与非RA患者以性别和年龄作为匹配变量,通过倾向评分进行1:1匹配。使用多变量条件logistic回归分析评估匹配的506名参与者中RA与呼吸道变态反应性疾病的相关性。经社会经济人口统计变量调整后,RA与呼吸道过敏性疾病患病率增加相关,OR为1.51 (95% CI, 1.31-1.75)。哮喘和变应性鼻炎患者中RA患病率的调整OR如下:3.12 (95% CI, 2.77-3.51)和1.39 (95% CI, 1.16-1.67)。患有哮喘的参与者患类风湿关节炎的风险增加。根据我们的发现,Th1和Th2疾病可能确实共存,其中一条途径可能刺激或促成另一条途径的发病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between Rheumatoid Arthritis and Respiratory Allergic Diseases in Korean Adults: A Propensity Score Matched Case-Control Study.

Rheumatoid arthritis (RA) and allergic diseases are result of a poor functioning immune system, giving dominance to either T-helper 1 (Th1) or T-helper 2 (Th2) diseases, respectively. Studies have stated that there seems to be a relationship present between the immune response subsets. This study was designed to examine the association between RA and respiratory allergic diseases in Korean adults. The study utilized the KNHANES 2013-2015 data and excluded individuals diagnosed with RA before being diagnosed with allergic diseases, using age at clinical diagnosis. Total of 253 RA patients were matched 1 : 1 with non-RA patients by a propensity score, using sex and age as matched variables. Multivariate conditional logistic regression analyses were used to evaluate for association between RA and respiratory allergic diseases in the matched 506 participants. RA was associated with an increased risk of prevalence of respiratory allergic diseases with an OR of 1.51 (95% CI, 1.31-1.75), adjusted for socioeconomic demographic variables. The adjusted OR for prevalence of RA among participants with prevalence of asthma and allergic rhinitis was as follows: 3.12 (95% CI, 2.77-3.51) and 1.39 (95% CI, 1.16-1.67). Participants with prevalence of asthma in particular had an increased risk of developing prevalence of RA. Based on our findings, Th1 and Th2 diseases may indeed coexist, and one pathway may stimulate or contribute towards the onset of the other.

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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
9
审稿时长
24 weeks
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