生殖细胞肿瘤生物学和治疗中的免疫相关概念。

IF 1.8 Q3 UROLOGY & NEPHROLOGY

Advances in Urology Pub Date : 2018-03-13 eCollection Date: 2018-01-01 DOI:10.1155/2018/3718165

Michal Chovanec, Ugo De Giorgi, Michal Mego

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引用次数: 0

摘要

生殖细胞瘤（GCT）通过化疗治愈率很高。挽救性化疗或手术可以治愈一部分患者，但无法治愈的患者将在年轻时死于疾病。免疫检查点通路正在成为强大的靶向生物标记物，目前正在进行大量临床前和临床研究，以拓宽我们的知识面，扩大免疫疗法的治疗可能性。目前，许多实体瘤都采用了免疫调节的概念，但对 GCT 的研究还不够。在此，我们总结了目前已发表文献中有关 GCTs 免疫机制和免疫疗法的知识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Immune-Related Concepts in Biology and Treatment of Germ-Cell Tumors.

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Immune-Related Concepts in Biology and Treatment of Germ-Cell Tumors.

Germ-cell tumors (GCTs) are highly curable with chemotherapy. Salvage chemotherapy or surgery can cure a proportion of patients, but the ones failing these treatments will die of their disease in the young age. Immune checkpoint pathways are emerging as powerful targetable biomarkers, and a significant preclinical and clinical research is underway to widen our knowledge and expand the treatment possibilities with immune therapy. The concept of immune modulation that was currently adopted in many solid tumors is understudied in GCTs. Herein, we summarize the current knowledge of published literature discussing the immune mechanisms and immune therapy in GCTs.

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来源期刊

Advances in Urology UROLOGY & NEPHROLOGY-

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Advances in Urology is a peer-reviewed, open access journal that publishes state-of-the-art reviews and original research papers of wide interest in all fields of urology. The journal strives to provide publication of important manuscripts to the widest possible audience worldwide, without the constraints of expensive, hard-to-access, traditional bound journals. Advances in Urology is designed to improve publication access of both well-established urologic scientists and less well-established writers, by allowing interested scientists worldwide to participate fully.