自闭症谱系障碍的拟人化、代理和社会归因背后的脑反应。

Q4 Medicine
Open Neuroimaging Journal Pub Date : 2018-03-30 eCollection Date: 2018-01-01 DOI:10.2174/1874440001812010016
Carla J Ammons, Constance F Doss, David Bala, Rajesh K Kana
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引用次数: 6

摘要

背景:在自闭症谱系障碍(ASD)中,心理理论(ToM)是一种将自己和他人的精神状态归因于自己的能力,它经常受到损害,可能是由于大脑社会区域激活的改变。相反,典型发展型(TD)个体过度扩展ToM,并表现出强烈的拟人化和解释环境中生物运动的倾向。关于拟人化程度如何影响ASD中社会大脑的故意归因和参与,人们知之甚少。目的:本fMRI研究利用一系列人体简笔画和几何图形,探讨ASD和TD患者的拟人化程度、拟人化在社会归因中的作用以及潜在的神经反应。方法:14名ASD和14名TD成年人在fMRI扫描仪上观看简笔画和三角形以随机或有社会意义的方式互动的视频。此外,他们还完成了扫描之外的ToM技能和现实社会缺陷测试。采用SPM12实现的一般线性模型,对所有条件下的全脑统计分析进行回归和组内组间比较。结果:在ASD和TD患者中,ToM网络区域被激活以响应社会运动和类人特征。此外,在观看简笔画时,更强的ToM能力与TPJ和MPFC活动增加有关;而更严重的社交症状则与社交运动导致的右侧TPJ激活减少有关。结论:拟人化程度对ASD社会归因无显著影响,提示TPJ在ToM和社会归因中的重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Brain Responses Underlying Anthropomorphism, Agency, and Social Attribution in Autism Spectrum Disorder.

Brain Responses Underlying Anthropomorphism, Agency, and Social Attribution in Autism Spectrum Disorder.

Brain Responses Underlying Anthropomorphism, Agency, and Social Attribution in Autism Spectrum Disorder.

Brain Responses Underlying Anthropomorphism, Agency, and Social Attribution in Autism Spectrum Disorder.

Background: Theory of Mind (ToM), the ability to attribute mental states to oneself and others, is frequently impaired in Autism Spectrum Disorder (ASD) and may result from altered activation of social brain regions. Conversely, Typically Developing (TD) individuals overextend ToM and show a strong tendency to anthropomorphize and interpret biological motion in the environment. Less is known about how the degree of anthropomorphism influences intentional attribution and engagement of the social brain in ASD.

Objective: This fMRI study examines the extent of anthropomorphism, its role in social attribution, and the underlying neural responses in ASD and TD using a series of human stick figures and geometrical shapes.

Methods: 14 ASD and 14 TD adults watched videos of stick figures and triangles interacting in random or socially meaningful ways while in an fMRI scanner. In addition, they completed out-of-scanner measures of ToM skill and real-world social deficits. Whole brain statistical analysis was performed for regression and within and between group comparisons of all conditions using SPM12's implementation of the general linear model.

Results: ToM network regions were activated in response to social movement and human-like characters in ASD and TD. In addition, greater ToM ability was associated with increased TPJ and MPFC activity while watching stick figures; whereas more severe social symptoms were associated with reduced right TPJ activation in response to social movement.

Conclusion: These results suggest that degree of anthropomorphism does not differentially affect social attribution in ASD and highlights the importance of TPJ in ToM and social attribution.

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来源期刊
Open Neuroimaging Journal
Open Neuroimaging Journal Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
0.70
自引率
0.00%
发文量
3
期刊介绍: The Open Neuroimaging Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, and letters in all important areas of brain function, structure and organization including neuroimaging, neuroradiology, analysis methods, functional MRI acquisition and physics, brain mapping, macroscopic level of brain organization, computational modeling and analysis, structure-function and brain-behavior relationships, anatomy and physiology, psychiatric diseases and disorders of the nervous system, use of imaging to the understanding of brain pathology and brain abnormalities, cognition and aging, social neuroscience, sensorimotor processing, communication and learning.
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