大鼠肩袖修复后法氏囊组织间充质干细胞的迁移。

Q1 Medicine
Joints Pub Date : 2018-03-13 eCollection Date: 2018-03-01 DOI:10.1055/s-0038-1636948
Elem Safi, Andreas Ficklscherer, Maryna Bondarava, Oliver Betz, Anja Zhang, Volkmar Jansson, Peter E Müller
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引用次数: 8

摘要

目的验证大鼠肩袖修复后法氏囊组织间充质干细胞向愈合部位的迁移。方法采用Fischer大鼠和绿色荧光蛋白(GFP)转基因大鼠。分离GFP大鼠的法氏囊组织并将其移植到Fischer大鼠的肌腱修复部位。我们检查了术后1、3和6周修复后的肩袖的组织学和gfp阳性细胞的比例。结果术后第3周和第6周观察到细胞迁移。我们还在修复后的肌腱中发现了间充质干细胞和形成的法氏囊簇。结论间充质干细胞从法氏囊组织迁移并浸润修复后的肩袖肌腱。来自法氏囊组织的间充质干细胞有助于修复后的肩袖的愈合进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats.

Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats.

Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats.

Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats.

Purpose  The purpose of this study is to verify migration of mesenchymal stem cells of bursal tissue into the healing site after rotator cuff repair in rats. Methods  Fischer rats and green fluorescent protein (GFP)-transgenic rats were used. Bursal tissue from GFP rats was isolated and transplanted into tendon repair sites in Fischer rats. We examined the histology of the rotator cuff and the proportion of GFP-positive cells in the repaired rotator cuff 1, 3, and 6 weeks after surgery. Results  Cell migration was observed during the third and sixth week after surgery. We also found mesenchymal stem cells and formed bursal cluster patterns in the repaired rotator cuff tendons. Conclusion  Mesenchymal stem cells migrated from bursal tissue and infiltrated the repaired rotator cuff tendons. Clinical Relevance  Mesenchymal stem cells from bursal tissue can contribute to the healing progress of the repaired rotator cuff.

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来源期刊
Joints
Joints Medicine-Rehabilitation
CiteScore
4.30
自引率
0.00%
发文量
0
期刊介绍: Joints is the official publication of SIGASCOT (Italian Society of the Knee, Arthroscopy, Sports Traumatology, Cartilage and Orthopaedic Technology). As an Open Acccess journal, it publishes papers on clinical and basic research, review articles, technical notes, case reports, and editorials about the latest developments in knee surgery, arthroscopy, sports traumatology, cartilage, orthopaedic technology, upper limb, and related rehabilitation. Letters to the Editor and comments on the journal''s content are always welcome.
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