Elem Safi, Andreas Ficklscherer, Maryna Bondarava, Oliver Betz, Anja Zhang, Volkmar Jansson, Peter E Müller
{"title":"大鼠肩袖修复后法氏囊组织间充质干细胞的迁移。","authors":"Elem Safi, Andreas Ficklscherer, Maryna Bondarava, Oliver Betz, Anja Zhang, Volkmar Jansson, Peter E Müller","doi":"10.1055/s-0038-1636948","DOIUrl":null,"url":null,"abstract":"<p><p><b>Purpose</b> The purpose of this study is to verify migration of mesenchymal stem cells of bursal tissue into the healing site after rotator cuff repair in rats. <b>Methods</b> Fischer rats and green fluorescent protein (GFP)-transgenic rats were used. Bursal tissue from GFP rats was isolated and transplanted into tendon repair sites in Fischer rats. We examined the histology of the rotator cuff and the proportion of GFP-positive cells in the repaired rotator cuff 1, 3, and 6 weeks after surgery. <b>Results</b> Cell migration was observed during the third and sixth week after surgery. We also found mesenchymal stem cells and formed bursal cluster patterns in the repaired rotator cuff tendons. <b>Conclusion</b> Mesenchymal stem cells migrated from bursal tissue and infiltrated the repaired rotator cuff tendons. <b>Clinical Relevance</b> Mesenchymal stem cells from bursal tissue can contribute to the healing progress of the repaired rotator cuff.</p>","PeriodicalId":37852,"journal":{"name":"Joints","volume":"6 1","pages":"4-9"},"PeriodicalIF":0.0000,"publicationDate":"2018-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0038-1636948","citationCount":"8","resultStr":"{\"title\":\"Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats.\",\"authors\":\"Elem Safi, Andreas Ficklscherer, Maryna Bondarava, Oliver Betz, Anja Zhang, Volkmar Jansson, Peter E Müller\",\"doi\":\"10.1055/s-0038-1636948\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Purpose</b> The purpose of this study is to verify migration of mesenchymal stem cells of bursal tissue into the healing site after rotator cuff repair in rats. <b>Methods</b> Fischer rats and green fluorescent protein (GFP)-transgenic rats were used. Bursal tissue from GFP rats was isolated and transplanted into tendon repair sites in Fischer rats. We examined the histology of the rotator cuff and the proportion of GFP-positive cells in the repaired rotator cuff 1, 3, and 6 weeks after surgery. <b>Results</b> Cell migration was observed during the third and sixth week after surgery. We also found mesenchymal stem cells and formed bursal cluster patterns in the repaired rotator cuff tendons. <b>Conclusion</b> Mesenchymal stem cells migrated from bursal tissue and infiltrated the repaired rotator cuff tendons. <b>Clinical Relevance</b> Mesenchymal stem cells from bursal tissue can contribute to the healing progress of the repaired rotator cuff.</p>\",\"PeriodicalId\":37852,\"journal\":{\"name\":\"Joints\",\"volume\":\"6 1\",\"pages\":\"4-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-03-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1055/s-0038-1636948\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Joints\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1055/s-0038-1636948\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2018/3/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Joints","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/s-0038-1636948","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/3/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats.
Purpose The purpose of this study is to verify migration of mesenchymal stem cells of bursal tissue into the healing site after rotator cuff repair in rats. Methods Fischer rats and green fluorescent protein (GFP)-transgenic rats were used. Bursal tissue from GFP rats was isolated and transplanted into tendon repair sites in Fischer rats. We examined the histology of the rotator cuff and the proportion of GFP-positive cells in the repaired rotator cuff 1, 3, and 6 weeks after surgery. Results Cell migration was observed during the third and sixth week after surgery. We also found mesenchymal stem cells and formed bursal cluster patterns in the repaired rotator cuff tendons. Conclusion Mesenchymal stem cells migrated from bursal tissue and infiltrated the repaired rotator cuff tendons. Clinical Relevance Mesenchymal stem cells from bursal tissue can contribute to the healing progress of the repaired rotator cuff.
期刊介绍：
Joints is the official publication of SIGASCOT (Italian Society of the Knee, Arthroscopy, Sports Traumatology, Cartilage and Orthopaedic Technology). As an Open Acccess journal, it publishes papers on clinical and basic research, review articles, technical notes, case reports, and editorials about the latest developments in knee surgery, arthroscopy, sports traumatology, cartilage, orthopaedic technology, upper limb, and related rehabilitation. Letters to the Editor and comments on the journal''s content are always welcome.
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