补充姜黄对低维生素D系统性红斑狼疮患者给予维生素D3对疾病活动性(SLEDAI)、IL-6、TGF-β1血清的影响

IF 2.3 Q2 RHEUMATOLOGY
International Journal of Rheumatology Pub Date : 2017-01-01 Epub Date: 2017-12-28 DOI:10.1155/2017/7687053
C Singgih Wahono, Cameleia Diah Setyorini, Handono Kalim, Nurdiana Nurdiana, Kusworini Handono
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引用次数: 26

摘要

背景:姜黄中所含的姜黄素是一种与维生素d具有相似生物学效应的免疫调节剂。姜黄素与维生素D3联合使用有望发挥协同作用。目的:探讨补充姜黄对低维生素d SLE患者血清中维生素D3给药SLEDAI、IL-6、TGF-β1的影响。方法:采用双盲随机对照试验,于2016年1月- 2017年3月在马琅赛富安华医院进行。受试者SLE活动期(SLEDAI > 3), 25(OH)D3水平≤30 ng/ml,分为两组:服用胆骨化醇3 × 400 IU +安慰剂3 × 1片(I组)和服用胆骨化醇3 × 400 IU +姜黄3 × 20 mg,疗程3个月(II组),评估治疗前后血清SLEDAI、维生素D、IL-6、TGF-β1水平。结果:治疗后各组患者SLEDAI降低、血清IL-6水平降低、血清TGF-β1水平升高均无显著差异。血清IL-6水平降低与SLEDAI降低呈正相关。结论。姜黄补充维生素D3对SLEDAI和血清IL-6、TGF-β1水平无影响。该临床试验注册号为NCT03155477。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effect of <i>Curcuma xanthorrhiza</i> Supplementation on Systemic Lupus Erythematosus Patients with Hypovitamin D Which Were Given Vitamin D<sub>3</sub> towards Disease Activity (SLEDAI), IL-6, and TGF-<i>β</i>1 Serum.

Effect of <i>Curcuma xanthorrhiza</i> Supplementation on Systemic Lupus Erythematosus Patients with Hypovitamin D Which Were Given Vitamin D<sub>3</sub> towards Disease Activity (SLEDAI), IL-6, and TGF-<i>β</i>1 Serum.

Effect of <i>Curcuma xanthorrhiza</i> Supplementation on Systemic Lupus Erythematosus Patients with Hypovitamin D Which Were Given Vitamin D<sub>3</sub> towards Disease Activity (SLEDAI), IL-6, and TGF-<i>β</i>1 Serum.

Effect of Curcuma xanthorrhiza Supplementation on Systemic Lupus Erythematosus Patients with Hypovitamin D Which Were Given Vitamin D3 towards Disease Activity (SLEDAI), IL-6, and TGF-β1 Serum.

Background: Curcumin contained in Curcuma xanthorrhiza is an immunomodulator that has similar biological effect as vitamin D. Combination of curcumin and vitamin D3 is expected to work synergistically.

Objective: To determine the effect of Curcuma xanthorrhiza supplementation on vitamin D3 administration to SLEDAI, IL-6, and TGF-β1 serum in SLE patients with hypovitamin D.

Methods: This was a double-blind RCT conducted in Saiful Anwar Hospital, Malang, in January 2016-March 2017. Subjects were SLE active (SLEDAI > 3) with levels of 25(OH)D3 ≤ 30 ng/ml and divided into two groups: those receiving cholecalciferol 3 × 400 IU and placebo 3 × 1 tablets (group I) and those receiving 3 × 400 IU cholecalciferol and Curcuma xanthorrhiza 3 × 20 mg for 3 months (group II). SLEDAI, levels of vitamin D, IL-6, and TGF-β1 in serum were evaluated before and after the treatment.

Results: There were no significant differences in SLEDAI reduction, decreased serum levels of IL-6, and increased levels of TGF-β1 serum among groups after the treatment. Decreased levels of serum IL-6 have a positive correlation with SLEDAI reduction. Conclusion. Curcuma xanthorrhiza supplementation on vitamin D3 had no effects on SLEDAI and serum levels of IL-6 and TGF-β1. This clinical trial is registered with NCT03155477.

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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
9
审稿时长
24 weeks
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