{"title":"补充姜黄对低维生素D系统性红斑狼疮患者给予维生素D3对疾病活动性(SLEDAI)、IL-6、TGF-β1血清的影响","authors":"C Singgih Wahono, Cameleia Diah Setyorini, Handono Kalim, Nurdiana Nurdiana, Kusworini Handono","doi":"10.1155/2017/7687053","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Curcumin contained in <i>Curcuma xanthorrhiza</i> is an immunomodulator that has similar biological effect as vitamin D. Combination of curcumin and vitamin D<sub>3</sub> is expected to work synergistically.</p><p><strong>Objective: </strong>To determine the effect of <i>Curcuma xanthorrhiza</i> supplementation on vitamin D<sub>3</sub> administration to SLEDAI, IL-6, and TGF-<i>β</i>1 serum in SLE patients with hypovitamin D.</p><p><strong>Methods: </strong>This was a double-blind RCT conducted in Saiful Anwar Hospital, Malang, in January 2016-March 2017. Subjects were SLE active (SLEDAI > 3) with levels of 25(OH)D3 ≤ 30 ng/ml and divided into two groups: those receiving cholecalciferol 3 × 400 IU and placebo 3 × 1 tablets (group I) and those receiving 3 × 400 IU cholecalciferol and <i>Curcuma xanthorrhiza</i> 3 × 20 mg for 3 months (group II). SLEDAI, levels of vitamin D, IL-6, and TGF-<i>β</i>1 in serum were evaluated before and after the treatment.</p><p><strong>Results: </strong>There were no significant differences in SLEDAI reduction, decreased serum levels of IL-6, and increased levels of TGF-<i>β</i>1 serum among groups after the treatment. Decreased levels of serum IL-6 have a positive correlation with SLEDAI reduction. <i>Conclusion. Curcuma xanthorrhiza</i> supplementation on vitamin D<sub>3</sub> had no effects on SLEDAI and serum levels of IL-6 and TGF-<i>β</i>1. This clinical trial is registered with NCT03155477.</p>","PeriodicalId":51715,"journal":{"name":"International Journal of Rheumatology","volume":"2017 ","pages":"7687053"},"PeriodicalIF":2.3000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/7687053","citationCount":"26","resultStr":"{\"title\":\"Effect of <i>Curcuma xanthorrhiza</i> Supplementation on Systemic Lupus Erythematosus Patients with Hypovitamin D Which Were Given Vitamin D<sub>3</sub> towards Disease Activity (SLEDAI), IL-6, and TGF-<i>β</i>1 Serum.\",\"authors\":\"C Singgih Wahono, Cameleia Diah Setyorini, Handono Kalim, Nurdiana Nurdiana, Kusworini Handono\",\"doi\":\"10.1155/2017/7687053\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Curcumin contained in <i>Curcuma xanthorrhiza</i> is an immunomodulator that has similar biological effect as vitamin D. Combination of curcumin and vitamin D<sub>3</sub> is expected to work synergistically.</p><p><strong>Objective: </strong>To determine the effect of <i>Curcuma xanthorrhiza</i> supplementation on vitamin D<sub>3</sub> administration to SLEDAI, IL-6, and TGF-<i>β</i>1 serum in SLE patients with hypovitamin D.</p><p><strong>Methods: </strong>This was a double-blind RCT conducted in Saiful Anwar Hospital, Malang, in January 2016-March 2017. Subjects were SLE active (SLEDAI > 3) with levels of 25(OH)D3 ≤ 30 ng/ml and divided into two groups: those receiving cholecalciferol 3 × 400 IU and placebo 3 × 1 tablets (group I) and those receiving 3 × 400 IU cholecalciferol and <i>Curcuma xanthorrhiza</i> 3 × 20 mg for 3 months (group II). SLEDAI, levels of vitamin D, IL-6, and TGF-<i>β</i>1 in serum were evaluated before and after the treatment.</p><p><strong>Results: </strong>There were no significant differences in SLEDAI reduction, decreased serum levels of IL-6, and increased levels of TGF-<i>β</i>1 serum among groups after the treatment. Decreased levels of serum IL-6 have a positive correlation with SLEDAI reduction. <i>Conclusion. Curcuma xanthorrhiza</i> supplementation on vitamin D<sub>3</sub> had no effects on SLEDAI and serum levels of IL-6 and TGF-<i>β</i>1. This clinical trial is registered with NCT03155477.</p>\",\"PeriodicalId\":51715,\"journal\":{\"name\":\"International Journal of Rheumatology\",\"volume\":\"2017 \",\"pages\":\"7687053\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2017-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1155/2017/7687053\",\"citationCount\":\"26\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Rheumatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2017/7687053\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2017/12/28 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Rheumatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2017/7687053","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/12/28 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
引用次数: 26
摘要
背景:姜黄中所含的姜黄素是一种与维生素d具有相似生物学效应的免疫调节剂。姜黄素与维生素D3联合使用有望发挥协同作用。目的:探讨补充姜黄对低维生素d SLE患者血清中维生素D3给药SLEDAI、IL-6、TGF-β1的影响。方法:采用双盲随机对照试验，于2016年1月- 2017年3月在马琅赛富安华医院进行。受试者SLE活动期(SLEDAI > 3)， 25(OH)D3水平≤30 ng/ml，分为两组:服用胆骨化醇3 × 400 IU +安慰剂3 × 1片(I组)和服用胆骨化醇3 × 400 IU +姜黄3 × 20 mg，疗程3个月(II组)，评估治疗前后血清SLEDAI、维生素D、IL-6、TGF-β1水平。结果:治疗后各组患者SLEDAI降低、血清IL-6水平降低、血清TGF-β1水平升高均无显著差异。血清IL-6水平降低与SLEDAI降低呈正相关。结论。姜黄补充维生素D3对SLEDAI和血清IL-6、TGF-β1水平无影响。该临床试验注册号为NCT03155477。
Effect of Curcuma xanthorrhiza Supplementation on Systemic Lupus Erythematosus Patients with Hypovitamin D Which Were Given Vitamin D3 towards Disease Activity (SLEDAI), IL-6, and TGF-β1 Serum.
Background: Curcumin contained in Curcuma xanthorrhiza is an immunomodulator that has similar biological effect as vitamin D. Combination of curcumin and vitamin D3 is expected to work synergistically.
Objective: To determine the effect of Curcuma xanthorrhiza supplementation on vitamin D3 administration to SLEDAI, IL-6, and TGF-β1 serum in SLE patients with hypovitamin D.
Methods: This was a double-blind RCT conducted in Saiful Anwar Hospital, Malang, in January 2016-March 2017. Subjects were SLE active (SLEDAI > 3) with levels of 25(OH)D3 ≤ 30 ng/ml and divided into two groups: those receiving cholecalciferol 3 × 400 IU and placebo 3 × 1 tablets (group I) and those receiving 3 × 400 IU cholecalciferol and Curcuma xanthorrhiza 3 × 20 mg for 3 months (group II). SLEDAI, levels of vitamin D, IL-6, and TGF-β1 in serum were evaluated before and after the treatment.
Results: There were no significant differences in SLEDAI reduction, decreased serum levels of IL-6, and increased levels of TGF-β1 serum among groups after the treatment. Decreased levels of serum IL-6 have a positive correlation with SLEDAI reduction. Conclusion. Curcuma xanthorrhiza supplementation on vitamin D3 had no effects on SLEDAI and serum levels of IL-6 and TGF-β1. This clinical trial is registered with NCT03155477.
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