依那西普与寻常型银屑病患者甲状腺功能的关系。

Clujul medical (1957) Pub Date : 2018-01-01 Epub Date: 2018-01-15 DOI:10.15386/cjmed-813
Iulia Ioana Roman, Teodora Mocan, Meda-Sandra Orasan, Elena Mihaela Jianu, Carmen-Angela Sfrangeu, Remus-Ioan Orasan
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引用次数: 0

摘要

背景和目的:寻常型银屑病是一种慢性炎症性皮肤病,需要长期服药才能避免复发。TNF-α 是银屑病治疗的靶向分子之一,似乎也与甲状腺疾病的发病机制有关。本研究旨在评估抗 TNF-α 治疗与甲状腺参数之间的关系:银屑病患者血清中三碘甲状腺原氨酸(T3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)和抗甲状腺过氧化物酶抗体(AbTPO)的水平:研究对象为44名寻常型银屑病患者(20名接受抗肿瘤坏死因子-α治疗(依那西普)的患者,24名既往未接受过系统治疗的患者)。对每位患者的血清激素、AbAntiTPO和TNF-α浓度进行了测量,并进行了甲状腺超声波评估:结果:未接受过系统治疗的患者血清中 FT4 的平均水平明显更高(p):我们仅发现未接受系统治疗的患者的FT4平均水平明显较高。此外,血清促甲状腺激素(TSH)水平与 TNF-α 呈负相关。根据我们的数据,在今后的研究中可能会将其与其他抗 TNF-α 疗法进行比较。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Relationship between etanercept and thyroid function in patients with psoriasis vulgaris.

Relationship between etanercept and thyroid function in patients with psoriasis vulgaris.

Relationship between etanercept and thyroid function in patients with psoriasis vulgaris.

Background and aim: Psoriasis vulgaris, a chronic inflammatory skin disease, requires a long term medication, in order to avoid relapsing episodes. TNF-alpha, one of the targeted molecule in psoriasis therapy, seems to be also involved in thyroid disorders etiopathogenesis. The aim of this study was to evaluate the relationship between anti TNF-alpha therapy and thyroid parameters: serum level of triiodothyronine (T3), free thyroxine (FT4), thyroid-stimulating hormone (TSH) and antithyroidperoxidase antibody (AbTPO) in psoriasis treated population.

Methods: The study was performed on 44 patients with psoriasis vulgaris (20 patients under antiTNF-alpha treatment (etanercept), 24 patients with no previous systemic therapy). Serum concentrations of hormones, AbAntiTPO and TNF-alpha were measured and a thyroid ultrasonographic evaluation was performed for each patient.

Results: The mean serum level of FT4 was significantly higher in patients with no systemic treatment (p<0.05). The patients treated with etanercept had a significantly higher level of TNF-alpha (p<0.05). No significant difference was observed for the other evaluated parameters. Also, we found a significant negative correlation between TNF-alpha and TSH levels (r=-0.366, p=0.015).

Conclusions: We only found that the mean level of FT4 was significantly higher in patients with no systemic treatment. Also, a negative strong correlation was seen between serum level of TSH and TNF-alpha. Based on our data, comparison with other anti TNF-alpha therapies might be of interest in future studies.

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