更好的阿片受体激动剂。

Q1 Chemistry
Syed Lal Badshah, Asad Ullah, Salim S Al-Showiman, Yahia Nasser Mabkhot
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引用次数: 3

摘要

这篇评论强调了最近发表在《自然》杂志上的一项研究,该研究基于结构发现了对阿片受体具有最小作用的新型镇痛化合物。Manglik等人选择性地靶向了基于Gi的μOR途径,而不是阿片样物质的β-阻滞素途径。数以百万计的化合物的计算筛选显示了几个胜任配体的列表。他们从这些配体中合成了对接得分最高的化合物,并通过添加侧残基进一步优化了这些化合物,使其与μOR的相互作用更好。PZM21是一种很有前途的选择性μOR激动剂。它具有较好的镇痛性能,呼吸抑制和便秘的副作用最小。这项工作是朝着更好的药物设计和合成方面迈出的一步,在人类蛋白质组中存在的靶向GPCR蛋白的有效性,特异性和最小的副作用方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Better agonist for the opioid receptors.

Better agonist for the opioid receptors.

This commentary highlights the recent work published in journal Nature on the structural based discovery of novel analgesic compounds for opioid receptors with minimal effects. Manglik et al. selectively targeted the Gi based μOR pathway instead of the β-arrestin pathway of the opioids. The computational screening of millions of compounds showed a list of several competent ligands. From these ligands they synthesized the compounds with the best docking score, which were further optimized by adding side residues for better interaction with the μOR. A promising compound, PZM21, was a selective agonist of μOR. It has better analgesic properties with minimal side effects of respiratory depression and constipation. This work is a step towards better drug designing and synthesizing in terms of efficacy, specificity with least side effects of targeted GPCR proteins present in the human proteome.

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来源期刊
Chemistry Central Journal
Chemistry Central Journal 化学-化学综合
CiteScore
4.40
自引率
0.00%
发文量
0
审稿时长
3.5 months
期刊介绍: BMC Chemistry is an open access, peer reviewed journal that considers all articles in the broad field of chemistry, including research on fundamental concepts, new developments and the application of chemical sciences to broad range of research fields, industry, and other disciplines. It provides an inclusive platform for the dissemination and discussion of chemistry to aid the advancement of all areas of research. Sections: -Analytical Chemistry -Organic Chemistry -Environmental and Energy Chemistry -Agricultural and Food Chemistry -Inorganic Chemistry -Medicinal Chemistry -Physical Chemistry -Materials and Macromolecular Chemistry -Green and Sustainable Chemistry
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