维生素E摄入和PPARG Pro12Ala多态性与脂联素水平的相互作用

Q Agricultural and Biological Sciences

Journal of Nutrigenetics and Nutrigenomics Pub Date : 2017-01-01 Epub Date: 2018-02-02 DOI:10.1159/000486160

Wendy Campos-Perez, Nathaly Torres-Castillo, Mariana Perez-Robles, Jose Francisco Muñoz-Valle, Barbara Vizmanos-Lamotte, Erika Martinez-Lopez

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引用次数: 3

摘要

背景/目的:摄入维生素E的一个有益作用是增强过氧化物酶体增殖物激活受体γ (PPARγ)活性，并随之上调脂联素的表达。本研究的目的是分析PPARG Pro12Ala多态性受试者的脂联素水平与维生素E摄入量的关系。方法:共纳入283例受试者。根据经过验证的3天食物消耗记录估计维生素E的总摄入量，并使用Nutritionist prom软件进行分析。Pro12Ala多态性(rs1801282)通过等位基因鉴别确定。采用ELISA法测定脂联素水平。结果:所有受试者均缺乏维生素E(1.50±1.78 mg/d)。高维生素E摄入水平和Pro12Ala/Ala12Ala基因型受试者血清脂联素水平显著高于Pro12Pro基因型受试者(4.4 [3.2-5.7]vs. 2.7 [2.0-3.5] μg/mL);P = 0.024)。结论:我们的研究结果表明，应鼓励增加维生素E的摄入，因为已有报道称维生素E通过激活PPARγ促进脂联素的表达。Pro12Pro基因型受试者血清脂联素水平低于Pro12Ala/Ala12Ala基因型受试者;因此，他们患代谢并发症的风险可能更高。

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Interaction of Vitamin E Intake and Pro12Ala Polymorphism of PPARG with Adiponectin Levels.

Background/aim: One of the beneficial effects associated with vitamin E intake is the enhancement of peroxisome proliferator-activated receptor gamma (PPARγ) activity and the consequent upregulation of adiponectin expression. The aim of this study was to analyze the adiponectin levels in subjects with the Pro12Ala polymorphism of PPARG according to vitamin E intake.

Methods: A total of 283 subjects were enrolled. Total vitamin E intake was estimated based on a validated 3-day food consumption record and analyzed using Nutritionist ProTM software. The Pro12Ala polymorphism (rs1801282) was determined by allelic discrimination. The adiponectin levels were measured by an ELISA assay.

Results: Vitamin E intake was deficient in all subjects (1.50 ± 1.78 mg/day). Subjects with higher vitamin E intake levels and the Pro12Ala/Ala12Ala genotype had statistically significant higher levels of serum adiponectin than subjects with the Pro12Pro genotype (4.4 [3.2-5.7] vs. 2.7 [2.0-3.5] μg/mL; p = 0.024).

Conclusions: Our results suggest that increased consumption of vitamin E should be encouraged since it has been reported that vitamin E promotes adiponectin expression via PPARγ activation. Subjects with Pro12Pro genotype had lower serum adiponectin levels than subjects with Pro12Ala/Ala12Ala genotype; therefore, they might be at higher risk of developing metabolic complications.

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来源期刊

Journal of Nutrigenetics and Nutrigenomics GENETICS & HEREDITY-NUTRITION & DIETETICS

CiteScore

1.86

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The emerging field of nutrigenetics and nutrigenomics is rapidly gaining importance, and this new international journal has been established to meet the needs of the investigators for a high-quality platform for their research. Endorsed by the recently founded "International Society of Nutrigenetics/Nutrigenomics", the ‘Journal of Nutrigenetics and Nutrigenomics’ welcomes contributions not only investigating the role of genetic variation in response to diet and that of nutrients in the regulation of gene expression, but is also open for articles covering all aspects of gene-environment interactions in the determination of health and disease.