加拿大不列颠哥伦比亚省牙医为儿童开的止痛药处方

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2017-08-01

Mahyar Etminan, M Reza Nouri, Mohit Sodhi, Bruce C Carleton

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引用次数: 0

摘要

目的:近年来，儿童阿片类镇痛药的使用、滥用和过度处方引起了人们的极大关注。然而，牙医开具儿童麻醉性和非麻醉性镇痛药处方的模式缺乏证据。方法:我们使用加拿大不列颠哥伦比亚省的全民处方药数据库(PharmaNet)来检查牙科手术周围镇痛药的处方和分发情况。我们检查了1997年至2013年间牙医为儿童开的所有药物，因为我们可以获得药物剂量和药物供应天数的数据。我们还研究了使用各种麻醉性和非麻醉性镇痛药和苯二氮卓类药物的趋势。结果:共有266891名儿童由牙医开具了至少1种研究药物。可待因是最常用的处方:50%的儿童服用可待因超过3天。可待因的使用时间在≥12岁的儿童中最长，最长为5天。结论:我们的研究表明，在16年的研究期间，牙医开具的可待因处方有所增加。50%的儿童由牙医开出可待因处方;处方持续时间太长，无法避免潜在的吗啡积累，也不符合当前的治疗指南。

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Dentists’ Prescribing of Analgesics for Children in British Columbia, Canada

Objective: Recently, there has been great interest in the use, abuse and over-prescribing of opioid analgesics for children. However, there is a paucity of evidence on patterns of prescribing of both narcotic and non-narcotic analgesics for children by dentists.

Methods: We used a population-wide prescription drug database (PharmaNet) in British Columbia, Canada, to examine prescribing and dispensing of analgesics surrounding dental procedures. We examined all drugs prescribed for children by dentists between 1997 and 2013, as we had access to data on drug doses and days of medication supply. We also examined trends in the use of various narcotic and non-narcotic analgesics and benzodiazepines.

Results: In total, 268 691 children were prescribed at least 1 study drug by a dentist. Codeine was the most frequently prescribed: 50% of children received codeine for more than 3 days. Duration of use of codeine was greatest among children ≥12 years, the longest duration of use being 5 days.

Conclusions: Our study reveals that codeine prescription by dentists increased over the 16-year study period. Codeine is prescribed by dentists for 50% of children; prescriptions are for too long a duration to avoid potential morphine accumulation and are not in line with current treatment guidelines.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.