轻度认知障碍和阿尔茨海默病的听觉事件相关电位。

IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY
Cassandra Morrison, Sheida Rabipour, Frank Knoefel, Christine Sheppard, Vanessa Taler
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引用次数: 40

摘要

背景:随着年龄的增长,轻度认知障碍更有可能发生,并且在轻度认知障碍(MCI)和阿尔茨海默病(AD)患者中变得更加明显。识别认知衰退的传统方法(即神经心理学测试和临床判断)可能导致认知障碍的假阳性诊断。脑电图(EEG)等工具提供了额外的认知处理措施,索引了与衰老、轻度认知障碍和AD相关的电生理变化。目的:回顾脑电图的相关文献,以确定听觉事件相关电位(ERPs)是否可以区分健康衰老、轻度认知损伤和AD。方法:检索Medline和PyscInfo两个电子数据库,检索2005年1月至2017年4月间发表的文章。如果文章包括:i) 60岁或以上的参与者,则考虑进行审查;ii)健康老年人或诊断为轻度认知障碍或AD的老年人;iii)至少一个听觉诱发的ERP成分。结果:我们的检索显示1532篇文章(删除重复后为800篇);通过标题/摘要审查排除719篇,在剩余的81篇文章中,30篇符合纳入标准。所有的研究都比较了三个选定人群中至少两个的认知功能。我们的研究结果表明,P300和N200成分可以区分健康的认知衰老、MCI和AD。结论:erp可能对MCI和AD引起的进行性认知改变敏感。P300和N200可能有助于识别可能从轻度认知损伤进展为AD的患者,并可能成为一种有价值的临床工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Auditory Event-related Potentials in Mild Cognitive Impairment and Alzheimer's Disease.

Background: Mild cognitive deficits are more likely to occur with increasing age, and become more pronounced for people diagnosed with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Conventional methods to identify cognitive declines (i.e., neuropsychological testing and clinical judgment) can lead to false positive diagnoses of cognitive impairment. Tools such as electroencephalography (EEG) offer additional measures of cognitive processing, indexing the electrophysiological changes associated with aging, MCI and AD.

Objective: We reviewed the literature on EEG to determine if auditory event-related potentials (ERPs) could distinguish between healthy aging, MCI, and AD.

Method: We searched two electronic databases (Medline and PyscInfo) for articles published between January 2005 and April 2017. Articles were considered for review if they included: i) participants 60 years of age or older; ii) healthy older adults or those diagnosed with MCI or AD; iii) at least one auditory elicited ERP component.

Results: Our search revealed 1532 articles (800 after removing duplicates); 719 were excluded through title/abstract review, and of the 81 remaining articles, 30 satisfied inclusion criteria. All studies compared cognitive function between at least two of the three selected populations. Our findings suggest that the P300 and N200 components may distinguish between healthy cognitive aging, MCI, and AD.

Conclusion: ERPs may be sensitive to progressive cognitive changes due to MCI and AD. The P300 and N200 may help identify patients who are likely to progress from MCI to AD, and could be a valuable clinical tool.

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来源期刊
Current Alzheimer research
Current Alzheimer research 医学-神经科学
CiteScore
4.00
自引率
4.80%
发文量
64
审稿时长
4-8 weeks
期刊介绍: Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.
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