当前细胞外囊泡介导的药物递送研究的障碍。

Journal of pharmacy and pharmaceutics Pub Date : 2017-01-01 Epub Date: 2017-10-27 DOI:10.15436/2377-1313.17.1331
Heedoo Lee, Duo Zhang, Ashish Rai, Yang Jin
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引用次数: 6

摘要

细胞外囊泡(Extracellular Vesicles, EVs)是由供细胞释放的纳米级细胞源性膜囊泡,在细胞间通讯中起重要作用。在这篇简短的文章中,我们讨论了目前在ev介导的药物递送研究中面临的障碍。目前普遍使用的药物递送载体是脂质体,脂质体是一种合成囊泡,这些囊泡通常与血清蛋白、巨噬细胞和其他先天免疫反应分子相互作用,可能在它们递送药物之前就被破坏了。然而,电动汽车具有与衍生它们的细胞相同的膜组成和相似的细胞表面标记,从而防止相互作用或引发免疫反应。此外,电动汽车已被用于传递分子通过紧密的细胞连接,如血脑屏障。这引起了人们对使用电动汽车作为一种新的药物输送方法的兴趣。在此,我们讨论了电动汽车在药理学研究中用作药物传递载体之前需要解决的潜在缺陷和困难。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Obstacles to Current Extracellular Vesicle-Mediated Drug Delivery Research.

The Obstacles to Current Extracellular Vesicle-Mediated Drug Delivery Research.

Extracellular Vesicles (EVs) are nanometer-sized cell-derived membrane vesicles that are released by donor cells and play an important role in intercellular communication. In this short communication, we discuss the obstacles currently faced in EV-mediated drug delivery research. The commonly used vehicle for drug delivery in prevalent practice are liposome's which are synthetic vesicles, these vesicles commonly interact with serum proteins, macrophages and other innate immune response molecules and may be destroyed before they can deliver the drug. EVs however have the same membrane compositions and similar cell surface markers as the cells from which they are derived which thus prevents interactions or provocations of an immune response. In addition, EVs have been used to deliver molecules across tight cellular junctions such as the blood brain barrier. This has led to an interest in using EVs as a novel method for drug delivery. We hereby discuss the potential pitfalls and difficulties that need to be addressed before EVs can be used as drug delivery vehicles in pharmacological research.

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