José L Steffani-Vallejo, Marion E Brunck, Erika Y Acosta-Cruz, Rafael Montiel, Francisco Barona-Gómez
{"title":"猿猴分枝杆菌人类定植的基因组学启示。","authors":"José L Steffani-Vallejo, Marion E Brunck, Erika Y Acosta-Cruz, Rafael Montiel, Francisco Barona-Gómez","doi":"10.1186/s40793-017-0291-x","DOIUrl":null,"url":null,"abstract":"<p><p><i>Mycobacterium simiae</i> (Karassova V, Weissfeiler J, Kraszanay E, Acta Microbiol Acad Sci Hung 12:275-82, 1965) is a slow-growing nontuberculous <i>Mycobacterium</i> species found in environmental niches, and recently evidenced as an opportunistic Human pathogen. We report here the genome of a clinical isolate of <i>M. simiae</i> (MsiGto) obtained from a patient in Guanajuato, Mexico. With a size of 6,684,413 bp, the genomic sequence of strain MsiGto is the largest of the three <i>M. simiae</i> genomes reported to date. Gene prediction revealed 6409 CDSs in total, including 6354 protein-coding genes and 52 RNA genes. Comparative genomic analysis identified shared features between strain MsiGto and the other two reported <i>M. simiae</i> genomes, as well as unique genes. Our data reveals that <i>M. simiae</i> MsiGto harbors virulence-related genes, such as <i>arcD</i>, ESAT-6, and those belonging to the antigen 85 complex and <i>mce</i> clusters, which may explain its successful transition to the human host. We expect the genome information of strain MsiGto will provide a better understanding of infective mechanisms and virulence of this emergent pathogen.</p>","PeriodicalId":21965,"journal":{"name":"Standards in Genomic Sciences","volume":"13 ","pages":"1"},"PeriodicalIF":0.0000,"publicationDate":"2018-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759803/pdf/","citationCount":"0","resultStr":"{\"title\":\"Genomic insights into <i>Mycobacterium simiae</i> human colonization.\",\"authors\":\"José L Steffani-Vallejo, Marion E Brunck, Erika Y Acosta-Cruz, Rafael Montiel, Francisco Barona-Gómez\",\"doi\":\"10.1186/s40793-017-0291-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Mycobacterium simiae</i> (Karassova V, Weissfeiler J, Kraszanay E, Acta Microbiol Acad Sci Hung 12:275-82, 1965) is a slow-growing nontuberculous <i>Mycobacterium</i> species found in environmental niches, and recently evidenced as an opportunistic Human pathogen. We report here the genome of a clinical isolate of <i>M. simiae</i> (MsiGto) obtained from a patient in Guanajuato, Mexico. With a size of 6,684,413 bp, the genomic sequence of strain MsiGto is the largest of the three <i>M. simiae</i> genomes reported to date. Gene prediction revealed 6409 CDSs in total, including 6354 protein-coding genes and 52 RNA genes. Comparative genomic analysis identified shared features between strain MsiGto and the other two reported <i>M. simiae</i> genomes, as well as unique genes. Our data reveals that <i>M. simiae</i> MsiGto harbors virulence-related genes, such as <i>arcD</i>, ESAT-6, and those belonging to the antigen 85 complex and <i>mce</i> clusters, which may explain its successful transition to the human host. We expect the genome information of strain MsiGto will provide a better understanding of infective mechanisms and virulence of this emergent pathogen.</p>\",\"PeriodicalId\":21965,\"journal\":{\"name\":\"Standards in Genomic Sciences\",\"volume\":\"13 \",\"pages\":\"1\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-01-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759803/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Standards in Genomic Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s40793-017-0291-x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2018/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Standards in Genomic Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s40793-017-0291-x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
Genomic insights into Mycobacterium simiae human colonization.
Mycobacterium simiae (Karassova V, Weissfeiler J, Kraszanay E, Acta Microbiol Acad Sci Hung 12:275-82, 1965) is a slow-growing nontuberculous Mycobacterium species found in environmental niches, and recently evidenced as an opportunistic Human pathogen. We report here the genome of a clinical isolate of M. simiae (MsiGto) obtained from a patient in Guanajuato, Mexico. With a size of 6,684,413 bp, the genomic sequence of strain MsiGto is the largest of the three M. simiae genomes reported to date. Gene prediction revealed 6409 CDSs in total, including 6354 protein-coding genes and 52 RNA genes. Comparative genomic analysis identified shared features between strain MsiGto and the other two reported M. simiae genomes, as well as unique genes. Our data reveals that M. simiae MsiGto harbors virulence-related genes, such as arcD, ESAT-6, and those belonging to the antigen 85 complex and mce clusters, which may explain its successful transition to the human host. We expect the genome information of strain MsiGto will provide a better understanding of infective mechanisms and virulence of this emergent pathogen.
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