Jie Bao, Chenjie Zhou, Jiaqing Zhang, Jiaqiang Mo, Qing Ye, Junming He, Jingfang Diao
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引用次数: 44
摘要
背景:长链非编码RNA FOXD2-AS1在非小细胞肺癌中高表达并促进恶性进展。然而，FOXD2-AS1在食管鳞状细胞癌(ESCC)中的作用尚不清楚。目的:本研究探讨FOXD2-AS1表达水平与ESCC患者预后的关系。方法:采用qRT-PCR方法对147例接受根治性手术切除的ESCC患者的癌组织及癌旁非肿瘤组织样本中FOXD2-AS1的表达进行检测。分析FOXD2-AS1表达水平与患者总生存率(OS)和无病生存期(DFS)的相关性。结果:FOXD2-AS1在ESCC组织中的表达明显高于癌旁非肿瘤组织(P< 0.001)。Kaplan-Meier分析显示，ESCC患者FOXD2-AS1高表达与预后不良相关。FOXD2-AS1高水平患者的OS和DFS均短于FOXD2-AS1低水平患者(P值分别为0.005和0.0001)。多因素分析显示，OS患者FOXD2-AS1表达风险比为1.66 (95% CI = 1.04 ~ 2.64, P= 0.033)， DFS患者FOXD2-AS1表达风险比为2.68 (95% CI = 1.49 ~ 4.82, P= 0.001)。结论:总的来说，我们的结果提供了令人信服的证据，FOXD2-AS1可以作为ESCC患者生存的预测指标。
Upregulation of the long noncoding RNA FOXD2-AS1 predicts poor prognosis in esophageal squamous cell carcinoma.
Background: The long non-coding RNA FOXD2-AS1 is highly expressed in non-small cell lung cancer and promotes malignant progression. However, the role of FOXD2-AS1 in esophageal squamous cell carcinoma (ESCC) is still unclear.
Objective: In this study, we examined the relationships between the expression level of FOXD2-AS1 and the outcome of ESCC patients.
Methods: Expression of FOXD2-AS1 was evaluated in cancer tissue and adjacent non-tumor tissue samples from 147 ESCC patients who received radical surgical resection using qRT-PCR. The correlations between the expression level of FOXD2-AS1 and patients' overall (OS) and disease free survival (DFS) were analyzed.
Results: FOXD2-AS1 expression was upregulated in ESCC tissue than that in adjacent non-tumor tissue samples (P< 0.001). Kaplan-Meier analysis showed that high FOXD2-AS1 expression was correlated with poor prognosis in ESCC patients. Patients with a high level of FOXD2-AS1 had a shorter OS and DFS than those with a low level of FOXD2-AS1 (P= 0.005 and 0.0001, respectively). On multivariate analysis, the hazard ratio of FOXD2-AS1 expression was 1.66 (95% CI = 1.04-2.64, P= 0.033) for OS and 2.68 (95% CI = 1.49-4.82, P= 0.001) for DFS.
Conclusions: Overall, our results provided convinced evidence that FOXD2-AS1 may serve as a predictive marker for ESCC patients' survival.
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