细胞因子靶向治疗斑秃:特应性皮炎和其他炎症性皮肤病的经验教训

Q2 Medicine

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2018-01-01 DOI:10.1016/j.jisp.2017.10.005

Kunal Malik , Emma Guttman-Yassky

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引用次数: 22

摘要

斑秃是一种t细胞介导的疾病，与其他炎症性疾病(特别是特应性皮炎)具有表型相似性，缺乏安全、有效、机制特异性的治疗方法。越来越多的数据表明，斑秃有辅助性T型1、辅助性T型2、辅助性T型17/IL-23和磷酸二酯酶途径的贡献。这些轴的拮抗作用正在进行评估，并可能阐明斑秃的潜在分子通路，推进这种疾病的转化革命。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cytokine Targeted Therapeutics for Alopecia Areata: Lessons from Atopic Dermatitis and Other Inflammatory Skin Diseases

Alopecia areata is a T-cell-mediated disease that shares phenotypic similarities with other inflammatory diseases, particularly atopic dermatitis, and lacks safe, effective, mechanism-specific treatments. Increasing data suggests that alopecia areata harbors contributions of T helper type 1, T helper type 2, T helper type 17/IL-23, and phosphodiesterase pathways. Antagonism of these axes is undergoing evaluation, and might elucidate the underlying molecular circuitry of alopecia areata, advancing the translational revolution for this disease.

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来源期刊

Journal of Investigative Dermatology Symposium Proceedings 医学-皮肤病学

自引率

0.00%

发文量

期刊介绍： Journal of Investigative Dermatology Symposium Proceedings (JIDSP) publishes peer-reviewed, invited papers relevant to all aspects of cutaneous biology and skin disease. Papers in the JIDSP are often initially presented at a scientific meeting. Potential topics include biochemistry, biophysics, carcinogenesis, cellular growth and regulation, clinical research, development, epidemiology and other population-based research, extracellular matrix, genetics, immunology, melanocyte biology, microbiology, molecular and cell biology, pathology, pharmacology and percutaneous absorption, photobiology, physiology, and skin structure.