Cell Therapy and Critical Limb Ischemia: Evidence and Window of Opportunity in Obesity.

Endothelial Cells (ECs) from pre-existing capillaries, followed by their proliferation, migration, and capillary formation [10]. By contrast, arteriogenesis describes the remodeling of existing collateral channels, so that they can deliver more blood flow to the limb [11]. Finally, adult vasculogenesis involves the recruitment of Endothelial Progenitor Cells (EPCs), which migrate from the bone marrow to the area of ischemia and differentiate to form new blood vessels [12].