基于大型多功能高密度CMOS微电极阵列系统的脑切片高密度测绘。

International Solid-State Sensors, Actuators and Microsystems Conference : [proceedings]. International Conference on Solid-State Sensors, Actuators, and Microsystems Pub Date : 2017-06-01 DOI:10.1109/TRANSDUCERS.2017.7994006

Vijay Viswam, Raziyeh Bounik, Amir Shadmani, Jelena Dragas, Marie Obien, Jan Müller, Yihui Chen, Andreas Hierlemann

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引用次数: 8

摘要

我们提出了一种基于cmos的高密度微电极阵列(HD-MEA)系统，该系统可以通过多种读出模式对体外脑切片进行高密度测绘。4.48×2.43 mm2阵列由59,760个微电极组成，间距为13.5µm(5487个电极/mm2)。整个系统具有2048个动作电位、32个局部场电位和32个电流记录通道、32个阻抗测量通道和28个神经递质检测通道以及16个电压/电流刺激通道。该系统可以实时、无标签地监测大脑切片的位置、大小、形态和电活动。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

High-Density Mapping of Brain Slices using a Large Multi-Functional High-Density CMOS Microelectrode Array System.

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High-Density Mapping of Brain Slices using a Large Multi-Functional High-Density CMOS Microelectrode Array System.

We present a CMOS-based high-density microelectrode array (HD-MEA) system that enables high-density mapping of brain slices in-vitro with multiple readout modalities. The 4.48×2.43 mm² array consists of 59,760 micro-electrodes at 13.5 µm pitch (5487 electrodes/mm²). The overall system features 2048 action-potential, 32 local-field-potential and 32 current recording channels, 32 impedance-measurement and 28 neurotransmitter-detection channels and 16 voltage/current stimulation channels. The system enables real-time and label-free monitoring of position, size, morphology and electrical activity of brain slices.

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来源期刊

International Solid-State Sensors, Actuators and Microsystems Conference : [proceedings]. International Conference on Solid-State Sensors, Actuators, and Microsystems

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