{"title":"在食物抗氧化剂存在的情况下，三油酸氧化过程中形成潜在有毒的羰基。","authors":"Marini Damanik, Michael Murkovic","doi":"10.1007/s00706-017-2036-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Abstract: </strong>A relation between oil uptake and cancer as well as induction of hepatic inflammation was shown earlier. It is discussed that the main oil oxidation products-hydroperoxides and carbonyls-might be the reason for the mentioned diseases. In this manuscript quantitative determination of aldehydes which are formed during oxidation of triolein-as a model substance-using the Rancimat 679 is described. The oxidation of 11 g of triolein is carried out at 120 °C sparging air with a flow of 20 dm<sup>3</sup>/h for 10 h. A series of aliphatic aldehydes starting from hexanal to decanal as well as decenal was identified by LC-MS/MS and quantified as DNPH derivatives. In addition, the total amount of carbonyls was determined. Based on the calibration with hexanal, all other dominant substances were in the similar concentration range with maximum concentrations of 1.6 µmol/cm<sup>3</sup> of hexanal, 2.3 µmol/cm<sup>3</sup> of heptanal, 2.5 µmol/cm<sup>3</sup> of octanal, 3.2 µmol/cm<sup>3</sup> of nonanal, 4.0 µmol/cm<sup>3</sup> of decanal after 6 h. The total amount of carbonyls reached a maximum after 6 h being 27 µmol/cm<sup>3</sup> for triolein without antioxidant. The results of this investigation will be a basis for further toxicological studies on oxidized oils.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":18766,"journal":{"name":"Monatshefte Fur Chemie","volume":"148 12","pages":"2031-2035"},"PeriodicalIF":1.7000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00706-017-2036-3","citationCount":"8","resultStr":"{\"title\":\"Formation of potentially toxic carbonyls during oxidation of triolein in the presence of alimentary antioxidants.\",\"authors\":\"Marini Damanik, Michael Murkovic\",\"doi\":\"10.1007/s00706-017-2036-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Abstract: </strong>A relation between oil uptake and cancer as well as induction of hepatic inflammation was shown earlier. It is discussed that the main oil oxidation products-hydroperoxides and carbonyls-might be the reason for the mentioned diseases. In this manuscript quantitative determination of aldehydes which are formed during oxidation of triolein-as a model substance-using the Rancimat 679 is described. The oxidation of 11 g of triolein is carried out at 120 °C sparging air with a flow of 20 dm<sup>3</sup>/h for 10 h. A series of aliphatic aldehydes starting from hexanal to decanal as well as decenal was identified by LC-MS/MS and quantified as DNPH derivatives. In addition, the total amount of carbonyls was determined. Based on the calibration with hexanal, all other dominant substances were in the similar concentration range with maximum concentrations of 1.6 µmol/cm<sup>3</sup> of hexanal, 2.3 µmol/cm<sup>3</sup> of heptanal, 2.5 µmol/cm<sup>3</sup> of octanal, 3.2 µmol/cm<sup>3</sup> of nonanal, 4.0 µmol/cm<sup>3</sup> of decanal after 6 h. The total amount of carbonyls reached a maximum after 6 h being 27 µmol/cm<sup>3</sup> for triolein without antioxidant. The results of this investigation will be a basis for further toxicological studies on oxidized oils.</p><p><strong>Graphical abstract: </strong></p>\",\"PeriodicalId\":18766,\"journal\":{\"name\":\"Monatshefte Fur Chemie\",\"volume\":\"148 12\",\"pages\":\"2031-2035\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2017-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/s00706-017-2036-3\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Monatshefte Fur Chemie\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1007/s00706-017-2036-3\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2017/10/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Monatshefte Fur Chemie","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s00706-017-2036-3","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/10/19 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Formation of potentially toxic carbonyls during oxidation of triolein in the presence of alimentary antioxidants.
Abstract: A relation between oil uptake and cancer as well as induction of hepatic inflammation was shown earlier. It is discussed that the main oil oxidation products-hydroperoxides and carbonyls-might be the reason for the mentioned diseases. In this manuscript quantitative determination of aldehydes which are formed during oxidation of triolein-as a model substance-using the Rancimat 679 is described. The oxidation of 11 g of triolein is carried out at 120 °C sparging air with a flow of 20 dm3/h for 10 h. A series of aliphatic aldehydes starting from hexanal to decanal as well as decenal was identified by LC-MS/MS and quantified as DNPH derivatives. In addition, the total amount of carbonyls was determined. Based on the calibration with hexanal, all other dominant substances were in the similar concentration range with maximum concentrations of 1.6 µmol/cm3 of hexanal, 2.3 µmol/cm3 of heptanal, 2.5 µmol/cm3 of octanal, 3.2 µmol/cm3 of nonanal, 4.0 µmol/cm3 of decanal after 6 h. The total amount of carbonyls reached a maximum after 6 h being 27 µmol/cm3 for triolein without antioxidant. The results of this investigation will be a basis for further toxicological studies on oxidized oils.
期刊介绍：
"Monatshefte für Chemie/Chemical Monthly" was originally conceived as an Austrian journal of chemistry. It has evolved into an international journal covering all branches of chemistry. Featuring the most recent advances in research in analytical chemistry, biochemistry, inorganic, medicinal, organic, physical, structural, and theoretical chemistry, Chemical Monthly publishes refereed original papers and a section entitled "Short Communications". Reviews, symposia in print, and issues devoted to special fields will also be considered.
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