Neil G Burnet, Jessica E Scaife, Marina Romanchikova, Simon J Thomas, Amy M Bates, Emma Wong, David J Noble, Leila Ea Shelley, Simon J Bond, Julia R Forman, Andrew Cf Hoole, Gillian C Barnett, Frederic M Brochu, Michael Pd Simmons, Raj Jena, Karl Harrison, Ping Lin Yeap, Amelia Drew, Emma Silvester, Patrick Elwood, Hannah Pullen, Andrew Sultana, Shannon Yk Seah, Megan Z Wilson, Simon G Russell, Richard J Benson, Yvonne L Rimmer, Sarah J Jefferies, Nicolette Taku, Mark Gurnell, Andrew S Powlson, Carola-Bibiane Schönlieb, Xiaohao Cai, Michael Pf Sutcliffe, Michael A Parker
{"title":"将物理科学技术和欧洲核子研究中心技术应用于癌症放射治疗中尚未解决的问题：多学科“VoxTox”研究计划。","authors":"Neil G Burnet, Jessica E Scaife, Marina Romanchikova, Simon J Thomas, Amy M Bates, Emma Wong, David J Noble, Leila Ea Shelley, Simon J Bond, Julia R Forman, Andrew Cf Hoole, Gillian C Barnett, Frederic M Brochu, Michael Pd Simmons, Raj Jena, Karl Harrison, Ping Lin Yeap, Amelia Drew, Emma Silvester, Patrick Elwood, Hannah Pullen, Andrew Sultana, Shannon Yk Seah, Megan Z Wilson, Simon G Russell, Richard J Benson, Yvonne L Rimmer, Sarah J Jefferies, Nicolette Taku, Mark Gurnell, Andrew S Powlson, Carola-Bibiane Schönlieb, Xiaohao Cai, Michael Pf Sutcliffe, Michael A Parker","doi":"10.23726/cij.2017.457","DOIUrl":null,"url":null,"abstract":"<p><p>The VoxTox research programme has applied expertise from the physical sciences to the problem of radiotherapy toxicity, bringing together expertise from engineering, mathematics, high energy physics (including the Large Hadron Collider), medical physics and radiation oncology. In our initial cohort of 109 men treated with curative radiotherapy for prostate cancer, daily image guidance computed tomography (CT) scans have been used to calculate delivered dose to the rectum, as distinct from planned dose, using an automated approach. Clinical toxicity data have been collected, allowing us to address the hypothesis that delivered dose provides a better predictor of toxicity than planned dose.</p>","PeriodicalId":53416,"journal":{"name":"CERN IdeaSquare Journal of Experimental Innovation","volume":"1 1","pages":"3-12"},"PeriodicalIF":0.0000,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701740/pdf/emss-74722.pdf","citationCount":"0","resultStr":"{\"title\":\"Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: the multidisciplinary 'VoxTox' research programme.\",\"authors\":\"Neil G Burnet, Jessica E Scaife, Marina Romanchikova, Simon J Thomas, Amy M Bates, Emma Wong, David J Noble, Leila Ea Shelley, Simon J Bond, Julia R Forman, Andrew Cf Hoole, Gillian C Barnett, Frederic M Brochu, Michael Pd Simmons, Raj Jena, Karl Harrison, Ping Lin Yeap, Amelia Drew, Emma Silvester, Patrick Elwood, Hannah Pullen, Andrew Sultana, Shannon Yk Seah, Megan Z Wilson, Simon G Russell, Richard J Benson, Yvonne L Rimmer, Sarah J Jefferies, Nicolette Taku, Mark Gurnell, Andrew S Powlson, Carola-Bibiane Schönlieb, Xiaohao Cai, Michael Pf Sutcliffe, Michael A Parker\",\"doi\":\"10.23726/cij.2017.457\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The VoxTox research programme has applied expertise from the physical sciences to the problem of radiotherapy toxicity, bringing together expertise from engineering, mathematics, high energy physics (including the Large Hadron Collider), medical physics and radiation oncology. In our initial cohort of 109 men treated with curative radiotherapy for prostate cancer, daily image guidance computed tomography (CT) scans have been used to calculate delivered dose to the rectum, as distinct from planned dose, using an automated approach. Clinical toxicity data have been collected, allowing us to address the hypothesis that delivered dose provides a better predictor of toxicity than planned dose.</p>\",\"PeriodicalId\":53416,\"journal\":{\"name\":\"CERN IdeaSquare Journal of Experimental Innovation\",\"volume\":\"1 1\",\"pages\":\"3-12\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701740/pdf/emss-74722.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"CERN IdeaSquare Journal of Experimental Innovation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.23726/cij.2017.457\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Decision Sciences\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"CERN IdeaSquare Journal of Experimental Innovation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23726/cij.2017.457","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Decision Sciences","Score":null,"Total":0}
Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: the multidisciplinary 'VoxTox' research programme.
The VoxTox research programme has applied expertise from the physical sciences to the problem of radiotherapy toxicity, bringing together expertise from engineering, mathematics, high energy physics (including the Large Hadron Collider), medical physics and radiation oncology. In our initial cohort of 109 men treated with curative radiotherapy for prostate cancer, daily image guidance computed tomography (CT) scans have been used to calculate delivered dose to the rectum, as distinct from planned dose, using an automated approach. Clinical toxicity data have been collected, allowing us to address the hypothesis that delivered dose provides a better predictor of toxicity than planned dose.
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