适用于微流控技术的无生物污损 PDMS 表面改性策略的最新进展。

TECHNOLOGY Pub Date : 2017-03-01 Epub Date: 2017-02-07 DOI:10.1142/S2339547817300013
Aslihan Gokaltun, Martin L Yarmush, Ayse Asatekin, O Berk Usta
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引用次数: 0

摘要

在过去的十年中,包括快速原型技术在内的微加工工艺发展迅速,并已达到相当成熟的阶段。这些进步鼓励并使更多用户能够使用微流体设备,并将其应用于生物分离、细胞和类器官培养。因此,该领域目前面临的一个重大挑战是控制界面上的生物分子相互作用,以及开发新型生物材料,以满足生物医学应用的独特需求。聚二甲基硅氧烷(PDMS)是微流体设备制造中使用最广泛的材料之一。这种材料之所以广受欢迎,是因为它成本低、制作简单、可快速制作原型、光学透明度高、气体渗透性好。然而,PDMS 的一个主要缺点是疏水性和表面亲水化后的快速疏水恢复。这导致蛋白质以及治疗药物等疏水小分子的大量非特异性吸附,限制了 PDMS 在生物医学微流控电路中的应用。因此,我们在此重点介绍表面分子处理方面的最新进展,以防止 PDMS 表面结垢,从而提高其实用性并扩大其在生物医学应用中的使用范围。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Recent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technology.

Recent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technology.

Recent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technology.

In the last decade microfabrication processes including rapid prototyping techniques have advanced rapidly and achieved a fairly mature stage. These advances have encouraged and enabled the use of microfluidic devices by a wider range of users with applications in biological separations and cell and organoid cultures. Accordingly, a significant current challenge in the field is controlling biomolecular interactions at interfaces and the development of novel biomaterials to satisfy the unique needs of the biomedical applications. Poly(dimethylsiloxane) (PDMS) is one of the most widely used materials in the fabrication of microfluidic devices. The popularity of this material is the result of its low cost, simple fabrication allowing rapid prototyping, high optical transparency, and gas permeability. However, a major drawback of PDMS is its hydrophobicity and fast hydrophobic recovery after surface hydrophilization. This results in significant nonspecific adsorption of proteins as well as small hydrophobic molecules such as therapeutic drugs limiting the utility of PDMS in biomedical microfluidic circuitry. Accordingly, here, we focus on recent advances in surface molecular treatments to prevent fouling of PDMS surfaces towards improving its utility and expanding its use cases in biomedical applications.

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来源期刊
TECHNOLOGY
TECHNOLOGY ENGINEERING, MULTIDISCIPLINARY-
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