肥胖对甲状腺功能正常的沙特成年人血清甲状腺激素水平的影响

IF 1.7 Q4 ENDOCRINOLOGY & METABOLISM
Journal of Thyroid Research Pub Date : 2017-01-01 Epub Date: 2017-05-22 DOI:10.1155/2017/5739806
Hassan M Al-Musa
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引用次数: 25

摘要

研究目的:评估沙特成年人的血清甲状腺激素水平,并将参与者的血清水平与他们的体重指数(BMI)等级联系起来。方法:共招募278名成人受试者。参与者根据BMI等级分为正常体重(BMI < 25 kg/m2)、超重(BMI 25-29.9 kg/m2)和肥胖(BMI≥30 kg/m2)。在阿卜哈市阿西尔中心医院中心实验室用化学发光免疫分析法评估血清甲状腺激素水平。结果:超过四分之三的参与者超重(31.3%)或肥胖(44.6%)。平均血清TSH水平随BMI的增加呈显著升高趋势(p < 0.001)。参与者的平均血清fT4水平与BMI呈负相关趋势,但根据BMI,平均血清fT4水平没有显著差异。此外,根据BMI,血清fT3水平无显著差异。结论:血清TSH水平随BMI升高而升高。需要进一步的大规模多中心和纵向研究来证明甲状腺功能正常的成年人血清甲状腺激素水平与BMI之间的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of Obesity on Serum Levels of Thyroid Hormones among Euthyroid Saudi Adults.

Aim of study: To assess serum thyroid hormones levels among Saudi adults and to correlate participants' serum levels with their grades of body mass index (BMI).

Methodology: A total of 278 adult subjects were recruited. Participants were categorized according to their BMI grades into normal weight (BMI < 25 kg/m2), overweight (BMI 25-29.9 kg/m2), or obese (BMI ≥ 30 kg/m2). Serum thyroid hormones levels were assessed at the central laboratory of Aseer Central Hospital, Abha City, by chemiluminescence immunoassay.

Results: More than three-fourths of participants were either overweight (31.3%) or obese (44.6%). Mean TSH serum levels showed a significantly increasing trend with increasing BMI (p < 0.001). A negative trend was observed regarding participants' mean serum levels of fT4 with their BMI, but there were no significant differences in mean serum fT4 levels according to BMI. Moreover, no significant differences were observed in serum fT3 levels according to BMI.

Conclusions: Mean TSH serum levels increase with BMI increase. Further largescale multicentric and longitudinal studies are necessary to prove the association between serum levels of thyroid hormones and BMI of euthyroid adults.

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来源期刊
Journal of Thyroid Research
Journal of Thyroid Research ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
10
审稿时长
17 weeks
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