硒-迈克尔反应立体选择性合成4′-硒核苷

Q4 Chemistry

Current Protocols in Nucleic Acid Chemistry Pub Date : 2017-06-19 DOI:10.1002/cpnc.27

Pramod K. Sahu, Dnyandev B. Jarhad, Gyudong Kim, Lak Shin Jeong

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Stereoselective Synthesis of 4′-Selenonucleosides via the Seleno-Michael Reaction

5′-Homo-4′-selenonucleosides, a class of next-generation nucleosides, are synthesized from D-ribose via a 4-selenosugar intermediate. The key step in synthesizing this intermediate is a seleno-Michael reaction. 5′-Homo-4′-selenouridine and -adenosine are prepared using Pummerer-type and Vorbrüggen condensation, respectively. © 2017 by John Wiley & Sons, Inc.

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Current Protocols in Nucleic Acid Chemistry Chemistry-Organic Chemistry

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期刊介绍： Published in association with International Society for Nucleosides, Nucleotides & Nucleic Acids (IS3NA) , Current Protocols in Nucleic Acid Chemistry is equally valuable for biotech, pharmaceutical, and academic labs. It is the resource for designing and running successful research projects in the rapidly growing and changing field of nucleic acid, nucleotide, and nucleoside research.