暴露于生物质燃烧对COPD患者肺部炎症标志物和肺功能的影响

D. Ramos , M. Proença , M.R. Leite , A.D. Ferreira , I.B. Trevisan , G.F.S. Brígida , G.Y. Tacao , E.M.C. Ramos
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引用次数: 8

摘要

肺康复(PR)对慢性阻塞性肺病患者有许多好处。然而,目前尚不清楚公共关系是否可以防止空气污染的危害。本研究旨在分析生物质燃烧暴露对COPD患者、PR参与者和非PR参与者肺部炎症标志物和肺功能的影响。方法35名受试者分为三组:接受PR的COPD患者(G1, n = 15),未接受PR的患者(G2, n = 10),以及由非COPD健康个体组成的对照组(CG, n = 10)。测量呼出液样本的肺功能和IL-6、IL-10、TNF-α浓度。记录了生物质燃烧和非燃烧时期的颗粒物(PM10)、二氧化氮(NO2)、臭氧(O3)、温度(T)和相对空气湿度(RAH)的评估和浓度。结果生物质燃烧期大气污染物浓度明显升高。在此期间,COPD患者IL-6升高(G1p = 0.041, G2 p = 0.012), FEV1/FVC比值降低(G1p = 0.021, G2 p = 0.007)。G1期,IL-6浓度升高与O3呈正相关(r = 0.693;p = 0.006),与RAH呈负相关(r = - 0.773;P = .003)。结论:暴露于生物质燃烧的COPD个体表现出肺部炎症增加和FEV1/FVC比率降低,无论他们是否参与PR。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of exposure to biomass burning on pulmonary inflammatory markers and pulmonary function in individuals with COPD

Introduction

Pulmonary rehabilitation (PR) has many benefits for individuals with COPD. However, it is not clear whether PR could prevent the hazards of air pollution exposure. This study aimed to analyze the effects of biomass burning exposure on pulmonary inflammatory markers and pulmonary function in individuals with COPD, participants and non-participants of PR.

Methods

35 subjects were divided into three groups: individuals with COPD who received PR (G1, n = 15), those who did not (G2, n = 10), and a control group composed of healthy individuals without COPD (CG, n = 10). Measurements of lung function and concentrations of IL-6, IL-10, and TNF-α in exhaled breath condensate samples were collected. The assessment and concentrations of particulate matter (PM10), nitrogen dioxide (NO2), ozone (O3), temperature (T), and relative air humidity (RAH) were recorded in biomass burning and non-burning periods.

Results

There was a significant increase in the concentrations of air pollutants in the biomass burning period. In this period, an increase in IL-6 (G1p = 0.041, G2 p = .012), and a reduction in the FEV1/FVC ratio (G1p = 0.021, G2 p = .007) were observed in individuals with COPD. In G1, the increase in IL-6 concentrations correlated positively with O3 (r = 0.693; p = .006), and negatively with RAH (r = −0.773; p = .003) in the burning period.

Conclusions

Individuals with COPD exposed to biomass burning demonstrated increased pulmonary inflammation and a reduction in the FEV1/FVC ratio, regardless of their engagement in PR.

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