{"title":"轻度/轻度卵巢刺激对中期II期卵母细胞体外受精的影响。","authors":"John J Zhang, Mingxue Yang, Zaher Merhi","doi":"10.1186/s40738-016-0025-6","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>An inverse relationship between oocyte efficiency and ovarian response was reported in conventional IVF. The purpose of this study was to report metaphase II (MII) oocyte efficiency according to oocyte yield in minimal/mild stimulation IVF (mIVF) and to assess whether oocyte yield affects live birth rate (LBR).</p><p><strong>Methods: </strong>Infertile women (<i>n</i> = 264) aged < 39 years old with normal ovarian reserve who had mIVF were recruited. All participants received the same protocol for ovarian stimulation. All the embryos were cultured to the blastocyst stage and vitrified using a freeze-all approach. This was followed by a single blastocyst transferred to each participant in subsequent cycles over a 6-month period. Ovarian response was categorized according to the number of MII oocyte yield (low: 1-2, intermediate: 3-6 and high ≥ 7 MII oocytes). MII oocyte utilization rate was calculated as the number of live births divided by the number of MII oocytes produced after only one oocyte retrieval and subsequent transfers of vitrified/warmed blastocysts. The main outcome measure was cumulative LBR over a 6-month period.</p><p><strong>Results: </strong>Among all the participants, 1173 total retrieved oocytes (4.4 ± 0.2 per patient) resulted in 1019 (3.9 ± 0.2 per patient) total MII oocytes, a clinical pregnancy rate of 48.1 % and a LBR of 41.2 %. Oocyte utilization rate was inversely related to ovarian response where it was 30.3 % in the \"low\" vs. 9.3 % in the \"intermediate\" vs. 4.3 % in the \"high\" oocyte yield groups (<i>p</i> < 0.05). Implantation rate significantly dropped as the number of MII oocytes increased and was highest in the \"low\" oocyte yield group (<i>p</i> < 0.0001). Cumulative LBR was similar in \"low,\" \"intermediate,\" and \"high\" oocyte yield groups (<i>p</i> > 0.05). The number of MII oocytes had poor sensitivity and specificity for predicting a live birth.</p><p><strong>Conclusion: </strong>These data extend the hypothesis of oocyte efficiency reported in conventional IVF protocols to mIVF protocols.</p><p><strong>Trial registration: </strong>Registration clinicaltrials.gov: NCT00799929.</p>","PeriodicalId":87254,"journal":{"name":"Fertility research and practice","volume":"2 ","pages":"2"},"PeriodicalIF":0.0000,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40738-016-0025-6","citationCount":"2","resultStr":"{\"title\":\"Efficiency of metaphase II oocytes following minimal/mild ovarian stimulation in vitro fertilization.\",\"authors\":\"John J Zhang, Mingxue Yang, Zaher Merhi\",\"doi\":\"10.1186/s40738-016-0025-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>An inverse relationship between oocyte efficiency and ovarian response was reported in conventional IVF. The purpose of this study was to report metaphase II (MII) oocyte efficiency according to oocyte yield in minimal/mild stimulation IVF (mIVF) and to assess whether oocyte yield affects live birth rate (LBR).</p><p><strong>Methods: </strong>Infertile women (<i>n</i> = 264) aged < 39 years old with normal ovarian reserve who had mIVF were recruited. All participants received the same protocol for ovarian stimulation. All the embryos were cultured to the blastocyst stage and vitrified using a freeze-all approach. This was followed by a single blastocyst transferred to each participant in subsequent cycles over a 6-month period. Ovarian response was categorized according to the number of MII oocyte yield (low: 1-2, intermediate: 3-6 and high ≥ 7 MII oocytes). MII oocyte utilization rate was calculated as the number of live births divided by the number of MII oocytes produced after only one oocyte retrieval and subsequent transfers of vitrified/warmed blastocysts. The main outcome measure was cumulative LBR over a 6-month period.</p><p><strong>Results: </strong>Among all the participants, 1173 total retrieved oocytes (4.4 ± 0.2 per patient) resulted in 1019 (3.9 ± 0.2 per patient) total MII oocytes, a clinical pregnancy rate of 48.1 % and a LBR of 41.2 %. Oocyte utilization rate was inversely related to ovarian response where it was 30.3 % in the \\\"low\\\" vs. 9.3 % in the \\\"intermediate\\\" vs. 4.3 % in the \\\"high\\\" oocyte yield groups (<i>p</i> < 0.05). Implantation rate significantly dropped as the number of MII oocytes increased and was highest in the \\\"low\\\" oocyte yield group (<i>p</i> < 0.0001). Cumulative LBR was similar in \\\"low,\\\" \\\"intermediate,\\\" and \\\"high\\\" oocyte yield groups (<i>p</i> > 0.05). The number of MII oocytes had poor sensitivity and specificity for predicting a live birth.</p><p><strong>Conclusion: </strong>These data extend the hypothesis of oocyte efficiency reported in conventional IVF protocols to mIVF protocols.</p><p><strong>Trial registration: </strong>Registration clinicaltrials.gov: NCT00799929.</p>\",\"PeriodicalId\":87254,\"journal\":{\"name\":\"Fertility research and practice\",\"volume\":\"2 \",\"pages\":\"2\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1186/s40738-016-0025-6\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Fertility research and practice\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s40738-016-0025-6\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2016/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fertility research and practice","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s40738-016-0025-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2016/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
摘要
背景:据报道，在常规IVF中，卵母细胞效率与卵巢反应呈反比关系。本研究的目的是根据最小/轻度刺激试管婴儿(mIVF)的卵母细胞产量报告中期II (MII)卵母细胞效率，并评估卵母细胞产量是否影响活产率(LBR)。结果:共回收卵母细胞1173个(4.4±0.2个/例)，共回收MII卵母细胞1019个(3.9±0.2个/例)，临床妊娠率为48.1%，LBR为41.2%。卵母细胞利用率与卵巢反应呈负相关，“低”组为30.3%，“中等”组为9.3%，“高”组为4.3% (p p p > 0.05)。MII卵母细胞数量对预测活产的敏感性和特异性较差。结论:这些数据将传统IVF方案中报道的卵母细胞效率假设扩展到mIVF方案。试验注册:registration clinicaltrials.gov: NCT00799929。
Efficiency of metaphase II oocytes following minimal/mild ovarian stimulation in vitro fertilization.
Background: An inverse relationship between oocyte efficiency and ovarian response was reported in conventional IVF. The purpose of this study was to report metaphase II (MII) oocyte efficiency according to oocyte yield in minimal/mild stimulation IVF (mIVF) and to assess whether oocyte yield affects live birth rate (LBR).
Methods: Infertile women (n = 264) aged < 39 years old with normal ovarian reserve who had mIVF were recruited. All participants received the same protocol for ovarian stimulation. All the embryos were cultured to the blastocyst stage and vitrified using a freeze-all approach. This was followed by a single blastocyst transferred to each participant in subsequent cycles over a 6-month period. Ovarian response was categorized according to the number of MII oocyte yield (low: 1-2, intermediate: 3-6 and high ≥ 7 MII oocytes). MII oocyte utilization rate was calculated as the number of live births divided by the number of MII oocytes produced after only one oocyte retrieval and subsequent transfers of vitrified/warmed blastocysts. The main outcome measure was cumulative LBR over a 6-month period.
Results: Among all the participants, 1173 total retrieved oocytes (4.4 ± 0.2 per patient) resulted in 1019 (3.9 ± 0.2 per patient) total MII oocytes, a clinical pregnancy rate of 48.1 % and a LBR of 41.2 %. Oocyte utilization rate was inversely related to ovarian response where it was 30.3 % in the "low" vs. 9.3 % in the "intermediate" vs. 4.3 % in the "high" oocyte yield groups (p < 0.05). Implantation rate significantly dropped as the number of MII oocytes increased and was highest in the "low" oocyte yield group (p < 0.0001). Cumulative LBR was similar in "low," "intermediate," and "high" oocyte yield groups (p > 0.05). The number of MII oocytes had poor sensitivity and specificity for predicting a live birth.
Conclusion: These data extend the hypothesis of oocyte efficiency reported in conventional IVF protocols to mIVF protocols.
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