{"title":"甲状腺癌患者18F-FDG PET/CT显像刺激血清甲状腺球蛋白水平的最佳阈值","authors":"Hong Chai, Hu Zhang, Yong-Li Yu, Yun-Chao Gao","doi":"10.1007/s11596-017-1752-6","DOIUrl":null,"url":null,"abstract":"<p><p>This study was to explore the optimal threshold of thyroid-stimulating hormone (TSH)-stimulated serum thyroglobulin (s-Tg) for patients who were to receive <sup>18</sup>F-fluorodeoxyglucose (<sup>18</sup>F-FDG) PET/CT scan owing to clinical suspicion of differentiated thyroid cancer (DTC) recurrence but negative post-therapeutic <sup>131</sup>I whole-body scan (<sup>131</sup>I-WBS). A total of 60 qualified patients underwent PET/CT scanning from October 2010 to July 2014. The receiver operating characteristic (ROC) curve analyses showed that s-Tg levels over 49 μg/L led to the highest diagnostic accuracy of PET/CT to detect recurrence, with a sensitivity of 89.5% and a specificity of 90.9%. Besides, bivariate correlation analysis showed positive correlation between s-Tg levels and the maximum standardized uptake values (SUVmax) of <sup>18</sup>F-FDG in patients with positive PET/CT scanning, suggesting a significant influence of TSH both on Tg release and uptake of <sup>18</sup>F-FDG. So, positive PET/CT imaging is expected when patients have negative <sup>131</sup>I-WBS but s-Tg levels over 49 μg/L.</p>","PeriodicalId":15925,"journal":{"name":"Journal of Huazhong University of Science and Technology [Medical Sciences]","volume":"37 3","pages":"429-432"},"PeriodicalIF":0.0000,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11596-017-1752-6","citationCount":"1","resultStr":"{\"title\":\"Optimal threshold of stimulated serum thyroglobulin level for <sup>18</sup>F-FDG PET/CT imaging in patients with thyroid cancer.\",\"authors\":\"Hong Chai, Hu Zhang, Yong-Li Yu, Yun-Chao Gao\",\"doi\":\"10.1007/s11596-017-1752-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This study was to explore the optimal threshold of thyroid-stimulating hormone (TSH)-stimulated serum thyroglobulin (s-Tg) for patients who were to receive <sup>18</sup>F-fluorodeoxyglucose (<sup>18</sup>F-FDG) PET/CT scan owing to clinical suspicion of differentiated thyroid cancer (DTC) recurrence but negative post-therapeutic <sup>131</sup>I whole-body scan (<sup>131</sup>I-WBS). A total of 60 qualified patients underwent PET/CT scanning from October 2010 to July 2014. The receiver operating characteristic (ROC) curve analyses showed that s-Tg levels over 49 μg/L led to the highest diagnostic accuracy of PET/CT to detect recurrence, with a sensitivity of 89.5% and a specificity of 90.9%. Besides, bivariate correlation analysis showed positive correlation between s-Tg levels and the maximum standardized uptake values (SUVmax) of <sup>18</sup>F-FDG in patients with positive PET/CT scanning, suggesting a significant influence of TSH both on Tg release and uptake of <sup>18</sup>F-FDG. So, positive PET/CT imaging is expected when patients have negative <sup>131</sup>I-WBS but s-Tg levels over 49 μg/L.</p>\",\"PeriodicalId\":15925,\"journal\":{\"name\":\"Journal of Huazhong University of Science and Technology [Medical Sciences]\",\"volume\":\"37 3\",\"pages\":\"429-432\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/s11596-017-1752-6\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Huazhong University of Science and Technology [Medical Sciences]\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s11596-017-1752-6\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2017/6/6 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q\",\"JCRName\":\"Engineering\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Huazhong University of Science and Technology [Medical Sciences]","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s11596-017-1752-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/6/6 0:00:00","PubModel":"Epub","JCR":"Q","JCRName":"Engineering","Score":null,"Total":0}
Optimal threshold of stimulated serum thyroglobulin level for 18F-FDG PET/CT imaging in patients with thyroid cancer.
This study was to explore the optimal threshold of thyroid-stimulating hormone (TSH)-stimulated serum thyroglobulin (s-Tg) for patients who were to receive 18F-fluorodeoxyglucose (18F-FDG) PET/CT scan owing to clinical suspicion of differentiated thyroid cancer (DTC) recurrence but negative post-therapeutic 131I whole-body scan (131I-WBS). A total of 60 qualified patients underwent PET/CT scanning from October 2010 to July 2014. The receiver operating characteristic (ROC) curve analyses showed that s-Tg levels over 49 μg/L led to the highest diagnostic accuracy of PET/CT to detect recurrence, with a sensitivity of 89.5% and a specificity of 90.9%. Besides, bivariate correlation analysis showed positive correlation between s-Tg levels and the maximum standardized uptake values (SUVmax) of 18F-FDG in patients with positive PET/CT scanning, suggesting a significant influence of TSH both on Tg release and uptake of 18F-FDG. So, positive PET/CT imaging is expected when patients have negative 131I-WBS but s-Tg levels over 49 μg/L.
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