多附着点2-氧- 1,2 -二氢喹啉化学型的合成及其在药物开发中的应用

JSM Chemistry Pub Date : 2016-01-01 Epub Date: 2016-10-26

Alexander V Kurkin, Andrea Altieri, Ivan A Andreev, Asim K Debnath

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引用次数: 0

摘要

2-氧- 1,2 -二氢喹啉化学型在筛选化合物中具有代表性。然而，2-氧- 1,2 -二氢喹啉的化学空间尚未得到充分的研究。在这项工作中，我们报道了一个小而新颖的2-氧- 1,2 -二氢喹啉化合物阵列的合成，用于筛选目的，特别是在药物发现中，具有三个方便的多样性点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of 2-Oxo-1, 2-Dihydroquinoline Chemotype with Multiple Attachment Points as Novel Screening Compounds for Drug Discovery.

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Synthesis of 2-Oxo-1, 2-Dihydroquinoline Chemotype with Multiple Attachment Points as Novel Screening Compounds for Drug Discovery.

The 2-oxo-1, 2-dihydroquinoline Chemotype is well represented among screening compound collection. However, the chemical space of 2-oxo-1, 2-dihydroquinoline has not been thoroughly investigated. In this work we report the synthesis of a small but novel 2-oxo-1, 2-dihydroquinoline compound array for screening purposes, especially in drug discovery, possessing three convenient point of diversity.

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JSM Chemistry

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