Dag Eckersten, Christos Tsatsanis, Aleksander Giwercman, Laila Bruun, Mats Pihlsgård, Anders Christensson
{"title":"MicroRNA-155和抗<s:1>勒氏激素:慢性肾脏疾病男性生育能力低下的新潜在标志物","authors":"Dag Eckersten, Christos Tsatsanis, Aleksander Giwercman, Laila Bruun, Mats Pihlsgård, Anders Christensson","doi":"10.1159/000458711","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/aims: </strong>Men with terminal renal failure are often infertile. Anti-müllerian hormone (AMH), a marker of Sertoli cell function, is decreased among men with chronic kidney disease (CKD). Recently, a microRNA, miR-155, has been shown to be a potential marker for subfertility. We studied miR-155 and semen parameters in patients with CKD who were not yet on dialysis. We also aimed to study possible associations between AMH, miR-155, and semen parameters to evaluate them as markers of fertility.</p><p><strong>Methods: </strong>Thirty male patients with CKD 1-4 as well as 18 healthy controls were enrolled.</p><p><strong>Results: </strong>Serum levels of miR-155 were significantly higher among men with CKD stages 1-2 (4.51 ± 3.81 [<i>p</i> = 0.01]) and stages 3-4 (2.75 ± 1.77 [<i>p</i> = 0.006]) than in controls (1.09 ± 0.44). Sperm concentration was significantly lower among men with CKD 3-4 (42 ± 29) ×10<sup>6</sup>/mL compared to controls (88 ± 42) ×10<sup>6</sup>/mL (<i>p</i> = 0.011). High levels of miR-155 were associated with a relatively low sperm concentration (<i>p</i> = 0.02) and with a low total sperm number (<i>p</i> = 0.005). Low AMH levels were associated with a decreased percentage of motile sperm cells (<i>p</i> = 0.02).</p><p><strong>Conclusions: </strong>We conclude that men with stage 3-4 CKD had lower sperm concentrations than healthy fertile men and that increased serum miR-155 in men with stage 1-4 CKD was associated with semen parameters that indicate subfertility. Low AMH levels were associated with a low percentage of the total number of motile sperm cells. miR-155 and AMH may be potential markers of subfertility in men with CKD.</p>","PeriodicalId":56356,"journal":{"name":"Nephron Extra","volume":"7 1","pages":"33-41"},"PeriodicalIF":0.0000,"publicationDate":"2017-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000458711","citationCount":"10","resultStr":"{\"title\":\"MicroRNA-155 and Anti-Müllerian Hormone: New Potential Markers of Subfertility in Men with Chronic Kidney Disease.\",\"authors\":\"Dag Eckersten, Christos Tsatsanis, Aleksander Giwercman, Laila Bruun, Mats Pihlsgård, Anders Christensson\",\"doi\":\"10.1159/000458711\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background/aims: </strong>Men with terminal renal failure are often infertile. Anti-müllerian hormone (AMH), a marker of Sertoli cell function, is decreased among men with chronic kidney disease (CKD). Recently, a microRNA, miR-155, has been shown to be a potential marker for subfertility. We studied miR-155 and semen parameters in patients with CKD who were not yet on dialysis. We also aimed to study possible associations between AMH, miR-155, and semen parameters to evaluate them as markers of fertility.</p><p><strong>Methods: </strong>Thirty male patients with CKD 1-4 as well as 18 healthy controls were enrolled.</p><p><strong>Results: </strong>Serum levels of miR-155 were significantly higher among men with CKD stages 1-2 (4.51 ± 3.81 [<i>p</i> = 0.01]) and stages 3-4 (2.75 ± 1.77 [<i>p</i> = 0.006]) than in controls (1.09 ± 0.44). Sperm concentration was significantly lower among men with CKD 3-4 (42 ± 29) ×10<sup>6</sup>/mL compared to controls (88 ± 42) ×10<sup>6</sup>/mL (<i>p</i> = 0.011). High levels of miR-155 were associated with a relatively low sperm concentration (<i>p</i> = 0.02) and with a low total sperm number (<i>p</i> = 0.005). Low AMH levels were associated with a decreased percentage of motile sperm cells (<i>p</i> = 0.02).</p><p><strong>Conclusions: </strong>We conclude that men with stage 3-4 CKD had lower sperm concentrations than healthy fertile men and that increased serum miR-155 in men with stage 1-4 CKD was associated with semen parameters that indicate subfertility. Low AMH levels were associated with a low percentage of the total number of motile sperm cells. miR-155 and AMH may be potential markers of subfertility in men with CKD.</p>\",\"PeriodicalId\":56356,\"journal\":{\"name\":\"Nephron Extra\",\"volume\":\"7 1\",\"pages\":\"33-41\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-04-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1159/000458711\",\"citationCount\":\"10\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nephron Extra\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1159/000458711\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2017/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nephron Extra","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000458711","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
MicroRNA-155 and Anti-Müllerian Hormone: New Potential Markers of Subfertility in Men with Chronic Kidney Disease.
Background/aims: Men with terminal renal failure are often infertile. Anti-müllerian hormone (AMH), a marker of Sertoli cell function, is decreased among men with chronic kidney disease (CKD). Recently, a microRNA, miR-155, has been shown to be a potential marker for subfertility. We studied miR-155 and semen parameters in patients with CKD who were not yet on dialysis. We also aimed to study possible associations between AMH, miR-155, and semen parameters to evaluate them as markers of fertility.
Methods: Thirty male patients with CKD 1-4 as well as 18 healthy controls were enrolled.
Results: Serum levels of miR-155 were significantly higher among men with CKD stages 1-2 (4.51 ± 3.81 [p = 0.01]) and stages 3-4 (2.75 ± 1.77 [p = 0.006]) than in controls (1.09 ± 0.44). Sperm concentration was significantly lower among men with CKD 3-4 (42 ± 29) ×106/mL compared to controls (88 ± 42) ×106/mL (p = 0.011). High levels of miR-155 were associated with a relatively low sperm concentration (p = 0.02) and with a low total sperm number (p = 0.005). Low AMH levels were associated with a decreased percentage of motile sperm cells (p = 0.02).
Conclusions: We conclude that men with stage 3-4 CKD had lower sperm concentrations than healthy fertile men and that increased serum miR-155 in men with stage 1-4 CKD was associated with semen parameters that indicate subfertility. Low AMH levels were associated with a low percentage of the total number of motile sperm cells. miR-155 and AMH may be potential markers of subfertility in men with CKD.
期刊介绍：
An open-access subjournal to Nephron. ''Nephron EXTRA'' publishes additional high-quality articles that cannot be published in the main journal ''Nephron'' due to space limitations.
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