藏红花在大鼠海马衰老性氧化损伤中的作用。

Q1 Agricultural and Biological Sciences
Saeed Samarghandian, Mohsen Azimi-Nezhad, Fariborz Samini, Tahereh Farkhondeh
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引用次数: 15

摘要

背景:使用抗氧化饮食可能是抑制与年龄相关疾病相关的氧化应激的良好策略。藏红花是一种具有抗氧化特性的干柱头。本实验研究了藏红花对雌性老龄大鼠脂质过氧化和抗氧化能力的影响。方法:大鼠用藏红花乙醇提取物灌胃4周。在研究结束时,我们切除了大鼠的海马体。用匀浆评价丙二醛(MDA)、一氧化氮(NO)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物(GPx)、过氧化氢酶(CAT)和谷胱甘肽(GSH)的含量。最近也有专利建议使用藏红花及其梯度预防老化组织中的氧化应激。结果:老龄大鼠海马抗氧化酶活性显著降低,MDA和一氧化氮水平升高,与衰老有关。此外,藏红花处理有效降低海马MDA和NO水平,提高抗氧化能力。有一种可能性是,藏红花提取物通过诱导轻度氧化损伤,从而导致抗氧化酶的激活,从而起到促激素的作用。结论:藏红花具有明显的神经保护作用,对大鼠海马抗衰老氧化损伤具有一定的保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Role of Saffron in Attenuating Age-related Oxidative Damage in Rat Hippocampus.

Background: Using antioxidant diets may be a good strategy for the inhibition of oxidative stress connected to age-related disease. Saffron is a dried stigma of with antioxidant properties. This investigation was done to study the effects of saffron administration on lipid peroxidation and antioxidant status in female aged rats.

Methods: The rats were treated with the ethanolic extract of saffron for 4 weeks. At the end of our investigation, the hippocampi of rats were removed. The homogenate was used for the evaluation of malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), glutathione peroxides (GPx), catalase (CAT) and glutathione (GSH). There are recent patents also suggesting the use of saffron and its gradients for prevention of oxidative stress in aged tissues.

Result: The results showed that the aging was connected with a significant reduction in the activities of antioxidant enzymes, and an increase in MDA and nitric oxide levels in the hippocampus of aged rats. In addition, treatment of saffron was effective in reducing hippocampus MDA and NO levels and in increasing the antioxidant status. There is a possibility that saffron extract acts as a hormetin by inducing mild oxidative damage which leads to the activation of antioxidative enzymes.

Conclusion: Therefore, saffron exerted considerable neuroprotective effect and proved to be efficacious in protecting rat hippocampus against age-related oxidative damage.

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来源期刊
Recent patents on food, nutrition & agriculture
Recent patents on food, nutrition & agriculture Agricultural and Biological Sciences-Agronomy and Crop Science
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